Reactome | p-Y104-RAD52 [nucleoplasm]

p-Y104-RAD52 [nucleoplasm]

Stable Identifier

R-HSA-5686588

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Single Strand Annealing (SSA) (Homo sapiens)
        
        ABL1 phosphorylates RAD52 (Homo sapiens)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52 [nucleoplasm] (Homo sapiens)
        
        Association of RAD51 with RAD52:DNA double-strand break ends (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52 [nucleoplasm] (Homo sapiens)
        
        Association of RAD52 with the RPA complex at resected DNA DSBs (Homo sapiens)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52 [nucleoplasm] (Homo sapiens)
        
        ERCC1:XPF cleaves flaps generated by SSA (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52 [nucleoplasm] (Homo sapiens)
        
        RAD52 promotes single strand annealing at resected DNA DSBs (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52 [nucleoplasm] (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P43351 RAD52

Gene Names

RAD52

Chain

chain:1-418

Reference Genes

BioGPS Gene:5893 RAD52

COSMIC (genes):RAD52 RAD52

CTD Gene:5893 RAD52

dbSNP Gene:5893 RAD52

ENSEMBL:ENSG00000002016 RAD52

HGNC:9824 RAD52

KEGG Gene (Homo sapiens):5893 RAD52

Monarch:5893 RAD52

NCBI Gene:5893 RAD52

OMIM:600392 RAD52

UCSC:P43351 RAD52

Reference Transcript

Other Identifiers

0003830315

0004670670

1043_s_at

11731758_at

11731759_s_at

11731760_a_at

11731761_x_at

11746884_a_at

11746885_s_at

11746886_x_at

11748832_a_at

11749968_a_at

11752970_a_at

11753544_a_at

11753545_x_at

1899_s_at

205647_at

210630_s_at

211904_x_at

3439834

3439835

3439837

3439838

3439839

3439840

3439841

3439842

3439844

3439849

3439850

3439851

3439853

3439854

3439857

3439858

3439859

3439861

3439862

3439863

3439864

3439865

3439866

3439867

3439868

3439869

3439873

3439879

40744_at

5893

7960261

A_23_P64990

A_33_P3242703

GE58929

GO:0000724

GO:0000730

GO:0003674

GO:0003677

GO:0003697

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0006259

GO:0006281

GO:0006302

GO:0006310

GO:0006312

GO:0006950

GO:0006974

GO:0008150

GO:0010792

GO:0022607

GO:0032991

GO:0032993

GO:0034599

GO:0034641

GO:0042802

GO:0043226

GO:0045002

GO:0065003

GO:2000819

ILMN_1781345

L33262_s_at

PH_hs_0022642

TC12001087.hg

U27516_s_at

g4506394_3p_at

g4581007_3p_a_at

g4581009_3p_a_at

Participant Of

hasComponent

p-Y104-RAD52 heptamer [nucleoplasm]

Other forms of this molecule

SUMO1-K411,K412,K414-RAD52 [nucleoplasm]

RAD52 [nucleoplasm]

Inferred To

phospho-RAD52 [nucleoplasm] (Bos taurus)

phospho-RAD52 [nucleoplasm] (Canis familiaris)

phospho-RAD52 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-rad52 [nucleoplasm] (Danio rerio)

phospho-rad52 [nucleoplasm] (Xenopus tropicalis)

phospho-rad22 [nucleoplasm] (Schizosaccharomyces pombe)

Ghost homologue of p-Y104-RAD52 [nucleoplasm] (Gallus gallus)

phospho-pigRAD52 [nucleoplasm] (Sus scrofa)

phospho-Rad52 [nucleoplasm] (Mus musculus)

phospho-Rad52 [nucleoplasm] (Rattus norvegicus)

phospho-p-Y104-RAD52 [nucleoplasm] (Dictyostelium discoideum)

Modified Residues

Name

O4'-phospho-L-tyrosine at 104

Coordinate

104

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_016875258.1, XP_005253778.1, NP_602296.2, XP_005253777.1, NP_001284348.1, XP_011519293.1, NP_001284349.1, XP_011519292.1

OpenTargets

ENSG00000002016

GeneCards

P43351

HPA

ENSG00000002016-RAD52

Ensembl

ENST00000461568, ENSP00000443254, ENST00000544742, ENST00000430095, ENSG00000002016, ENSP00000440268, ENSP00000434703, ENSP00000351284, ENST00000468231, ENSP00000436008, ENST00000541619, ENSP00000438965, ENST00000358495, ENSP00000387901, ENST00000545564

PRO

P43351

PDB

1KN0, 5XRZ, 5XS0, 5JRB, 1H2I

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P43351 RAD52	3	p-Y104-RAD52 [nucleoplasm] (R-HSA-5686588) SUMO1-K411,K412,K414-RAD52 [nucleoplasm] (R-HSA-4568909) RAD52 [nucleoplasm] (R-HSA-62639)	0.82	7
UniProt:Q14191 WRN	2	WRN [nucleoplasm] (R-HSA-67387) SUMO1-K356,K496,K898-WRN [nucleoplasm] (R-HSA-4568904)	0.675	9
UniProt:Q06609 RAD51	2	p-T309-RAD51 [nucleoplasm] (R-HSA-5685231) RAD51 [nucleoplasm] (R-HSA-62637)	0.635	3
UniProt:P35244 RPA3	1	RPA3 [nucleoplasm] (R-HSA-68459)	0.623	3
UniProt:Q02548 PAX5	1	PAX5 [nucleoplasm] (R-HSA-158583)	0.556	3
UniProt:Q13952-2 NFYC			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:O00505 KPNA3	2	KPNA3 [cytosol] (R-HSA-1176070) KPNA3 [nucleoplasm] (R-HSA-1176061)	0.556	3
UniProt:P50221 MEOX1			0.556	3
IntAct:EBI-22370853 CCSB ORF ID			0.556	3
UniProt:Q8NG50 RDM1			0.556	5
UniProt:Q9H4B4 PLK3	1	PLK3 [nucleoplasm] (R-HSA-3222161)	0.556	3
UniProt:Q9NPI6 DCP1A	1	DCP1A [cytosol] (R-HSA-430043)	0.556	5

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