Activated ATM phosphorylates DCLRE1C

Stable Identifier
R-HSA-5686704
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated ATM phosphorylates DCLRE1C (ARTEMIS) at serine residue S645. S645 phosphorylation is necessary for the function of DCLRE1C in non-homologous end joining (NHEJ) (Riballo et al. 2004, Poinsignon et al. 2004, Chen et al. 2005).

Literature References
PubMed ID Title Journal Year
15723659 Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage

Chen, L, Morio, T, Minegishi, Y, Nakada, S, Nagasawa, M, Komatsu, K, Chessa, L, Villa, A, Lecis, D, Delia, D, Mizutani, S

Cancer Sci. 2005
15468306 Phosphorylation of Artemis following irradiation-induced DNA damage

Poinsignon, C, de Chasseval, R, Soubeyrand, S, Moshous, D, Fischer, A, Haché, RJ, de Villartay, JP

Eur. J. Immunol. 2004
15574327 A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci

Riballo, E, Kühne, M, Rief, N, Doherty, A, Smith, GC, Recio, MJ, Reis, C, Dahm, K, Fricke, A, Krempler, A, Parker, AR, Jackson, SP, Gennery, A, Jeggo, PA, Löbrich, M

Mol. Cell 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created