DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs

Stable Identifier
R-HSA-5686924
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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DCLRE1C (ARTEMIS) forms a stable complex with PRKDC (DNA-PKcs), even in the absence of DNA ends (Ma et al. 2002). Autophosphorylation of PRKDC as well as ATM-mediated phosphorylation of DCLRE1C are not prerequisites for the interaction of PRKDC and DCLRE1C (Ding et al.2003).

Literature References
PubMed ID Title Journal Year
12897153 Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.

Ding, Q, Reddy, YV, Wang, W, Woods, T, Douglas, P, Ramsden, DA, Lees-Miller, SP, Meek, K

Mol Cell Biol 2003
11955432 Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination.

Ma, Y, Pannicke, U, Schwarz, K, Lieber, MR

Cell 2002
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