Reactome | p-S189 MAPK6 [cytosol]

p-S189 MAPK6 [cytosol]

Stable Identifier

R-HSA-5687019

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ERK3, PRKM6

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External Reference Information

External Reference

UniProt:Q16659 MAPK6

Gene Names

MAPK6, ERK3, PRKM6

Chain

chain:1-721

Reference Genes

BioGPS Gene:5597 MAPK6

COSMIC (genes):MAPK6 MAPK6

CTD Gene:5597 MAPK6

dbSNP Gene:5597 MAPK6

ENSEMBL:ENSG00000069956 MAPK6 gene

HGNC:6879 MAPK6

KEGG Gene (Homo sapiens):5597 MAPK6

Monarch:5597 MAPK6

NCBI Gene:5597 MAPK6

OMIM:602904 MAPK6

UCSC:Q16659 MAPK6

Reference Transcript

Other Identifiers

0001170102

11722796_a_at

16801179

207121_s_at

243831_at

3098308

3111632

3111634

3133821

3246221

3246228

3511512

3511517

3594130

3594142

3594143

3594144

3594145

3594146

3594147

3594150

3594153

3594154

3594155

3594156

3594157

3594158

3594160

36926_at

3926771

5597

76525_at

7983763

A_23_P3204

A_24_P333663

GE728188

GE79439

GO:0000165

GO:0000166

GO:0003674

GO:0004672

GO:0004674

GO:0004707

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0006464

GO:0006468

GO:0007049

GO:0007165

GO:0008150

GO:0010468

GO:0016301

GO:0016310

GO:0016740

GO:0019899

GO:0019901

GO:0030154

GO:0032156

GO:0032991

GO:0035556

GO:0043167

GO:0043226

GO:0046982

GO:0048856

GO:0060999

GO:0071310

Hs.122812.0.A1_3p_at

ILMN_1757287

PH_hs_0029556

TC15000417.hg

X80692_at

g4506090_3p_a_at

Participant Of

input

hasComponent

hasMember

p-S MAPK6,4 [cytosol]

Other forms of this molecule

ub-MAPK6 [cytosol]

p-3S,T MAPK6 [nucleoplasm]

MAPK6 [nucleoplasm]

p-S189 MAPK6 [nucleoplasm]

MAPK6 [cytosol]

Inferred To

phospho-p-S189 MAPK6 [cytosol] (Caenorhabditis elegans)

phospho-p-S189 MAPK6 [cytosol] (Dictyostelium discoideum)

phospho-p-S189 MAPK6 [cytosol] (Plasmodium falciparum)

phospho-p-S189 MAPK6 [cytosol] (Sus scrofa)

phospho-Mapk6 [cytosol] (Mus musculus)

phospho-Mapk6 [cytosol] (Rattus norvegicus)

phospho-spm1 [cytosol] (Schizosaccharomyces pombe)

phospho-gska-3 [cytosol] (Caenorhabditis elegans)

phospho-sty1 [cytosol] (Schizosaccharomyces pombe)

phospho-SLT2 [cytosol] (Saccharomyces cerevisiae)

phospho-MAPK6 [cytosol] (Bos taurus)

phospho-MAPK6 [cytosol] (Canis familiaris)

phospho-MAPK6 [cytosol] (Gallus gallus)

phospho-HOG1 [cytosol] (Saccharomyces cerevisiae)

phospho-erkA [cytosol] (Dictyostelium discoideum)

phospho-pmk-3 [cytosol] (Caenorhabditis elegans)

phospho-mapk6 [cytosol] (Danio rerio)

phospho-mapk6 [cytosol] (Xenopus tropicalis)

phospho-SMK1 [cytosol] (Saccharomyces cerevisiae)

phospho-mpk-2 [cytosol] (Caenorhabditis elegans)

phospho-sma-5 [cytosol] (Caenorhabditis elegans)

Homologues of p-S189 MAPK6 [cytosol] (Caenorhabditis elegans)

Homologues of p-S189 MAPK6 [cytosol] (Dictyostelium discoideum)

Homologues of p-S189 MAPK6 [cytosol] (Plasmodium falciparum)

Homologues of p-S189 MAPK6 [cytosol] (Saccharomyces cerevisiae)

Homologues of p-S189 MAPK6 [cytosol] (Schizosaccharomyces pombe)

Modified Residues

Name

O-phospho-L-serine at 189

Coordinate

189

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_002739.1, XP_005254596.1, XP_005254595.1, XP_011520084.1, XP_005254594.1

ZINC - World Drugs

MK06_HUMAN

OpenTargets

ENSG00000069956

ZINC - FDA approved

MK06_HUMAN

ZINC - Substances

MK06_HUMAN

ZINC - Biogenic

MK06_HUMAN

ZINC target

Q16659

PRO

Q16659

PDB

2I6L

ZINC - Investigational

MK06_HUMAN

HPA

ENSG00000069956-MAPK6

GeneCards

Q16659

Ensembl

ENSG00000069956, ENSP00000261845, ENST00000261845

ZINC - Predictions - Purchasable

MK06_HUMAN

HMDB Protein

HMDBP01527

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IW41 MAPKAPK5	5	p-S115 MAPKAPK5 [cytosol] (R-HSA-5687028) p-T182 MAPKAPK5 [cytosol] (R-HSA-5687004) p-S115 MAPKAPK5 [nucleoplasm] (R-HSA-5687026) MAPKAPK5 [nucleoplasm] (R-HSA-2562517) p-T182-MAPKAPK5 [nucleoplasm] (R-HSA-3239018)	0.848	7
UniProt:Q8IW41-2 MAPKAPK5			0.742	6
UniProt:O95714 HERC2	5	HERC2 [cytosol] (R-HSA-975975) SUMO1-HERC2 [nucleoplasm] (R-HSA-4551758) p-T4827,SUMO1-HERC2 [nucleoplasm] (R-HSA-5682615) p-T4827-HERC2 [nucleoplasm] (R-HSA-5682601) HERC2 [nucleoplasm] (R-HSA-4551680)	0.725	5
UniProt:Q9H6Z9 EGLN3	2	EGLN3 [cytosol] (R-HSA-1234115) EGLN3 [nucleoplasm] (R-HSA-1234104)	0.681	6
UniProt:Q9GZV1 ANKR2			0.556	7
UniProt:Q99613 EIF3C	1	EIF3C [cytosol] (R-HSA-72550)	0.547	2
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.547	2
UniProt:P02647 APOA1	11	Variant apolipoprotein AI [extracellular region] (R-HSA-976865) APOA1(25-266) [endocytic vesicle lumen] (R-HSA-2239460) APOA1(25-266) [secretory granule lumen] (R-HSA-350761) APOA1(25-267) [endoplasmic reticulum lumen] (R-HSA-174640) APOA1(19-266) [extracellular region] (R-HSA-264771) APOA1(25-266) [plasma membrane] (R-HSA-216742) APOA1(25-267) [early endosome] (R-HSA-2429641) APOA1(25-267) [cytosol] (R-HSA-2395781) APOA1(25-266) [extracellular region] (R-HSA-174720) p-APOA1 [endoplasmic reticulum lumen] (R-HSA-8957081) APOA1 [endoplasmic reticulum lumen] (R-HSA-8956724)	0.547	2
UniProt:P53350 PLK1	4	p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [cytosol] (R-HSA-164603)	0.547	2
UniProt:Q96GD4 AURKB	3	AURKB [nucleoplasm] (R-HSA-4655360) SUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414) AURKB [cytosol] (R-HSA-174231)	0.527	2
UniProt:Q6P1M0 SLC27A4	6	SLC27A4 R583H [plasma membrane] (R-HSA-5627897) SLC27A4 A92T [plasma membrane] (R-HSA-5627896) SLC27A4 Q300R [plasma membrane] (R-HSA-5627918) SLC27A4 S247P [plasma membrane] (R-HSA-5627907) SLC27A4 C168* [plasma membrane] (R-HSA-5627910) SLC27A4 [plasma membrane] (R-HSA-879638)	0.527	2
UniProt:Q96JN8-2 NEURL4			0.527	5
UniProt:Q96JN8 NEUL4			0.527	2
UniProt:Q9Y4C2 TCAF1			0.527	3
UniProt:Q14147 DHX34			0.527	2
UniProt:Q13011 ECH1	2	ECH1(1-328) [cytosol] (R-HSA-9033152) ECH1(1-328) [peroxisomal matrix] (R-HSA-9033140)	0.527	2
UniProt:Q8IZT6 ASPM			0.527	2
UniProt:Q71UM5 RPS27L	2	RPS27L [cytosol] (R-HSA-8868849) RPS27L [nucleoplasm] (R-HSA-6791197)	0.527	2
UniProt:O14965 AURKA	6	AURKA [nucleoplasm] (R-HSA-4655443) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [cytosol] (R-HSA-2574832)	0.527	2
UniProt:P12504 VIF			0.499	2

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