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p-S189 MAPK6 [cytosol]
Stable Identifier
R-HSA-5687019
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ERK3, PRKM6
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
MAPK4,6 translocate to nucleus (Homo sapiens)
MAPK4,6 [cytosol] (Homo sapiens)
p-S MAPK6,4 [cytosol] (Homo sapiens)
p-S189 MAPK6 [cytosol] (Homo sapiens)
MAPK4,6 translocate to the cytoplasm (Homo sapiens)
MAPK4,6 [cytosol] (Homo sapiens)
p-S MAPK6,4 [cytosol] (Homo sapiens)
p-S189 MAPK6 [cytosol] (Homo sapiens)
MAPKAPK5 phosphorylates KALRN (Homo sapiens)
KALRN:p-S189 MAPK6:p-T182 MAPKAPK5 [cytosol] (Homo sapiens)
p-S189 MAPK6 [cytosol] (Homo sapiens)
p-KALRN:p-S189 MAPK6:p-T182 MAPKAPK5 [cytosol] (Homo sapiens)
p-S189 MAPK6 [cytosol] (Homo sapiens)
PAK1,2,3 phosphorylates MAPK6,4 (Homo sapiens)
p-S MAPK6,4 [cytosol] (Homo sapiens)
p-S189 MAPK6 [cytosol] (Homo sapiens)
SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Homo sapiens)
SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 [cytosol] (Homo sapiens)
p-S189 MAPK6 [cytosol] (Homo sapiens)
p-S189 MAPK6 [cytosol] (Homo sapiens)
SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Homo sapiens)
SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 [cytosol] (Homo sapiens)
p-S189 MAPK6 [cytosol] (Homo sapiens)
p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Homo sapiens)
p-S MAPK6,4 [cytosol] (Homo sapiens)
p-S189 MAPK6 [cytosol] (Homo sapiens)
p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Homo sapiens)
KALRN:p-S189 MAPK6:p-T182 MAPKAPK5 [cytosol] (Homo sapiens)
p-S189 MAPK6 [cytosol] (Homo sapiens)
p-S189 MAPK6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16659 MAPK6
Gene Names
MAPK6, ERK3, PRKM6
Chain
chain:1-721
Reference Genes
BioGPS Gene:5597 MAPK6
COSMIC (genes):MAPK6 MAPK6
CTD Gene:5597 MAPK6
dbSNP Gene:5597 MAPK6
ENSEMBL:ENSG00000069956 MAPK6 gene
HGNC:6879 MAPK6
KEGG Gene (Homo sapiens):5597 MAPK6
Monarch:5597 MAPK6
NCBI Gene:5597 MAPK6
OMIM:602904 MAPK6
UCSC:Q16659 MAPK6
Reference Transcript
RefSeq:XM_011521782.1 MAPK6
RefSeq:XM_005254539.3 MAPK6
RefSeq:XM_005254537.2 MAPK6
RefSeq:NM_002748.3 MAPK6
RefSeq:XM_005254538.2 MAPK6
Other Identifiers
0001170102
11722796_a_at
16801179
207121_s_at
243831_at
3098308
3111632
3111634
3133821
3246221
3246228
3511512
3511517
3594130
3594142
3594143
3594144
3594145
3594146
3594147
3594150
3594153
3594154
3594155
3594156
3594157
3594158
3594160
36926_at
3926771
5597
76525_at
7983763
A_23_P3204
A_24_P333663
GE728188
GE79439
GO:0000165
GO:0000166
GO:0003674
GO:0004672
GO:0004674
GO:0004707
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006468
GO:0007049
GO:0007165
GO:0008150
GO:0010468
GO:0016301
GO:0016310
GO:0016740
GO:0035556
GO:0043167
GO:0043226
Hs.122812.0.A1_3p_at
ILMN_1757287
PH_hs_0029556
TC15000417.hg
X80692_at
g4506090_3p_a_at
Participant Of
input
p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN
SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5
hasComponent
KALRN:p-S189 MAPK6:p-T182 MAPKAPK5 [cytosol]
p-KALRN:p-S189 MAPK6:p-T182 MAPKAPK5 [cytosol]
SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 [cytosol]
hasMember
p-S MAPK6,4 [cytosol]
Other forms of this molecule
ub-MAPK6 [cytosol]
p-3S,T MAPK6 [nucleoplasm]
MAPK6 [nucleoplasm]
p-S189 MAPK6 [nucleoplasm]
MAPK6 [cytosol]
Inferred To
phospho-p-S189 MAPK6 [cytosol] (Caenorhabditis elegans)
phospho-p-S189 MAPK6 [cytosol] (Dictyostelium discoideum)
phospho-p-S189 MAPK6 [cytosol] (Plasmodium falciparum)
phospho-p-S189 MAPK6 [cytosol] (Sus scrofa)
phospho-Mapk6 [cytosol] (Mus musculus)
phospho-Mapk6 [cytosol] (Rattus norvegicus)
phospho-spm1 [cytosol] (Schizosaccharomyces pombe)
phospho-gska-3 [cytosol] (Caenorhabditis elegans)
phospho-sty1 [cytosol] (Schizosaccharomyces pombe)
phospho-SLT2 [cytosol] (Saccharomyces cerevisiae)
phospho-MAPK6 [cytosol] (Bos taurus)
phospho-MAPK6 [cytosol] (Canis familiaris)
phospho-MAPK6 [cytosol] (Gallus gallus)
phospho-HOG1 [cytosol] (Saccharomyces cerevisiae)
phospho-erkA [cytosol] (Dictyostelium discoideum)
phospho-pmk-3 [cytosol] (Caenorhabditis elegans)
phospho-mapk6 [cytosol] (Danio rerio)
phospho-mapk6 [cytosol] (Xenopus tropicalis)
phospho-SMK1 [cytosol] (Saccharomyces cerevisiae)
phospho-mpk-2 [cytosol] (Caenorhabditis elegans)
phospho-sma-5 [cytosol] (Caenorhabditis elegans)
Homologues of p-S189 MAPK6 [cytosol] (Caenorhabditis elegans)
Homologues of p-S189 MAPK6 [cytosol] (Dictyostelium discoideum)
Homologues of p-S189 MAPK6 [cytosol] (Plasmodium falciparum)
Homologues of p-S189 MAPK6 [cytosol] (Saccharomyces cerevisiae)
Homologues of p-S189 MAPK6 [cytosol] (Schizosaccharomyces pombe)
Modified Residues
Name
O-phospho-L-serine at 189
Coordinate
189
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_005254595.1
,
XP_011520084.1
,
NP_002739.1
,
XP_005254594.1
,
XP_005254596.1
ZINC - World Drugs
MK06_HUMAN
OpenTargets
ENSG00000069956
ZINC - FDA approved
MK06_HUMAN
ZINC - Substances
MK06_HUMAN
ZINC - Biogenic
MK06_HUMAN
ZINC target
Q16659
PRO
Q16659
PDB
2I6L
ZINC - Investigational
MK06_HUMAN
HPA
ENSG00000069956-MAPK6
GeneCards
Q16659
Ensembl
ENST00000261845
,
ENSP00000261845
,
ENSG00000069956
ZINC - Predictions - Purchasable
MK06_HUMAN
HMDB Protein
HMDBP01527
Interactors (20)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8IW41 MAPKAPK5
5
p-S115 MAPKAPK5 [cytosol]
(R-HSA-5687028)
p-T182 MAPKAPK5 [cytosol]
(R-HSA-5687004)
p-S115 MAPKAPK5 [nucleoplasm]
(R-HSA-5687026)
MAPKAPK5 [nucleoplasm]
(R-HSA-2562517)
p-T182-MAPKAPK5 [nucleoplasm]
(R-HSA-3239018)
0.848
7
UniProt:Q8IW41-2 MAPKAPK5
0.742
6
UniProt:O95714 HERC2
5
HERC2 [cytosol]
(R-HSA-975975)
SUMO1-HERC2 [nucleoplasm]
(R-HSA-4551758)
p-T4827,SUMO1-HERC2 [nucleoplasm]
(R-HSA-5682615)
p-T4827-HERC2 [nucleoplasm]
(R-HSA-5682601)
HERC2 [nucleoplasm]
(R-HSA-4551680)
0.725
5
UniProt:Q9H6Z9 EGLN3
2
EGLN3 [nucleoplasm]
(R-HSA-1234104)
EGLN3 [cytosol]
(R-HSA-1234115)
0.681
6
UniProt:Q9GZV1 ANKR2
0.556
7
UniProt:Q99613 EIF3C
1
EIF3C [cytosol]
(R-HSA-72550)
0.547
2
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.547
2
UniProt:P53350 PLK1
4
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
PLK1 [cytosol]
(R-HSA-164603)
0.547
2
UniProt:P02647 APOA1
11
Variant apolipoprotein AI [extracellular region]
(R-HSA-976865)
APOA1(25-266) [endocytic vesicle lumen]
(R-HSA-2239460)
APOA1(25-266) [secretory granule lumen]
(R-HSA-350761)
APOA1(25-267) [endoplasmic reticulum lumen]
(R-HSA-174640)
APOA1(19-266) [extracellular region]
(R-HSA-264771)
APOA1(25-266) [plasma membrane]
(R-HSA-216742)
APOA1(25-267) [early endosome]
(R-HSA-2429641)
APOA1(25-267) [cytosol]
(R-HSA-2395781)
APOA1(25-266) [extracellular region]
(R-HSA-174720)
p-APOA1 [endoplasmic reticulum lumen]
(R-HSA-8957081)
APOA1 [endoplasmic reticulum lumen]
(R-HSA-8956724)
0.547
2
UniProt:Q96GD4 AURKB
3
AURKB [nucleoplasm]
(R-HSA-4655360)
SUMO2,3-K202-AURKB [cytosol]
(R-HSA-4655414)
AURKB [cytosol]
(R-HSA-174231)
0.527
2
UniProt:Q6P1M0 SLC27A4
6
SLC27A4 R583H [plasma membrane]
(R-HSA-5627897)
SLC27A4 A92T [plasma membrane]
(R-HSA-5627896)
SLC27A4 Q300R [plasma membrane]
(R-HSA-5627918)
SLC27A4 S247P [plasma membrane]
(R-HSA-5627907)
SLC27A4 C168* [plasma membrane]
(R-HSA-5627910)
SLC27A4 [plasma membrane]
(R-HSA-879638)
0.527
2
UniProt:Q96JN8-2 NEURL4
0.527
5
UniProt:Q96JN8 NEUL4
0.527
2
UniProt:Q9Y4C2 TCAF1
0.527
3
UniProt:Q14147 DHX34
0.527
2
UniProt:Q13011 ECH1
2
ECH1(1-328) [cytosol]
(R-HSA-9033152)
ECH1(1-328) [peroxisomal matrix]
(R-HSA-9033140)
0.527
2
UniProt:Q8IZT6 ASPM
0.527
2
UniProt:O14965 AURKA
6
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
AURKA [nucleoplasm]
(R-HSA-4655443)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
AURKA [cytosol]
(R-HSA-174254)
p-T288-AURKA [cytosol]
(R-HSA-2574832)
0.527
2
UniProt:Q71UM5 RPS27L
2
RPS27L [cytosol]
(R-HSA-8868849)
RPS27L [nucleoplasm]
(R-HSA-6791197)
0.527
2
UniProt:P12504 VIF
0.499
2
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