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p-S115 MAPKAPK5 [nucleoplasm]
Stable Identifier
R-HSA-5687026
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
PRAK, MAP kinase-activated protein kinase 5, p38-regulated/activated protein kinase
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
PKA phosphorylates MAPKAPK5 (Homo sapiens)
p-S115 MAPKAPK5 [nucleoplasm] (Homo sapiens)
p-S115 MAPKAPK5 translocates to the cytosol (Homo sapiens)
p-S115 MAPKAPK5 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IW41 MAPKAPK5
Gene Names
MAPKAPK5, PRAK
Chain
chain:1-473
Reference Genes
BioGPS Gene:8550 MAPKAPK5
COSMIC (genes):MAPKAPK5 MAPKAPK5
CTD Gene:8550 MAPKAPK5
dbSNP Gene:8550 MAPKAPK5
ENSEMBL:ENSG00000089022 MAPKAPK5
HGNC:6889 MAPKAPK5
KEGG Gene (Homo sapiens):8550 MAPKAPK5
Monarch:8550 MAPKAPK5
NCBI Gene:8550 MAPKAPK5
OMIM:606723 MAPKAPK5
UCSC:Q8IW41 MAPKAPK5
Reference Transcript
RefSeq:NM_003668.3 MAPKAPK5
RefSeq:NM_139078.2 MAPKAPK5
Other Identifiers
0005720446
11723970_at
16757181
16757209
212871_at
228925_at
3432139
3432140
3432145
3432146
3432147
3432148
3432149
3432150
3432151
3432153
3432156
3432157
3432160
3432161
3432163
3432167
3432168
3432169
3432170
3432171
3432172
3432173
3432174
3432175
3432176
3432179
3432180
3432181
3432182
3432183
3432184
3432185
3432186
3432187
3432188
3432189
3432204
3432206
3432208
3432210
3432212
3432214
41506_at
7958800
8550
86882_at
A_14_P113146
A_14_P200357
A_21_P0000668
A_23_P87810
A_24_P124662
GE54249
GE716401
GE831332
GE87779
GO:0000165
GO:0000166
GO:0000187
GO:0002039
GO:0003674
GO:0004672
GO:0004674
GO:0004708
GO:0005515
GO:0005516
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006259
GO:0006412
GO:0006417
GO:0006464
GO:0006468
GO:0006950
GO:0007165
GO:0007265
GO:0007568
GO:0008150
GO:0009058
GO:0009931
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0019899
GO:0032007
GO:0032212
GO:0034641
GO:0035556
GO:0042592
GO:0043167
GO:0043226
GO:0046777
GO:0051019
GO:0051276
GO:0051973
GO:0090400
GO:1901796
GO:1904355
Hs.207422.0.A1_3p_at
Hs.30327.0.S1_3p_at
ILMN_1699082
ILMN_2322935
PH_hs_0024960
TC12000872.hg
TC12000873.hg
TC12002570.hg
Participant Of
output
PKA phosphorylates MAPKAPK5
input
p-S115 MAPKAPK5 translocates to the cytosol
Other forms of this molecule
p-T182 MAPKAPK5 [cytosol]
p-S115 MAPKAPK5 [cytosol]
MAPKAPK5 [nucleoplasm]
p-T182-MAPKAPK5 [nucleoplasm]
Inferred To
phospho-CPK3 [nucleoplasm] (Plasmodium falciparum)
phospho-CPK2 [nucleoplasm] (Plasmodium falciparum)
phospho-Mapkapk5 [nucleoplasm] (Mus musculus)
phospho-Mapkapk5 [nucleoplasm] (Rattus norvegicus)
phospho-CPK4 [nucleoplasm] (Plasmodium falciparum)
phospho-CPK1 [nucleoplasm] (Plasmodium falciparum)
Homologues of p-S115 MAPKAPK5 [nucleoplasm] (Dictyostelium discoideum)
Homologues of p-S115 MAPKAPK5 [nucleoplasm] (Plasmodium falciparum)
phospho-mapkapk5 [nucleoplasm] (Danio rerio)
phospho-mapkapk5 [nucleoplasm] (Xenopus tropicalis)
phospho-MAPKAPK5 [nucleoplasm] (Bos taurus)
phospho-MAPKAPK5 [nucleoplasm] (Canis familiaris)
phospho-MAPKAPK5 [nucleoplasm] (Gallus gallus)
phospho-p-S115 MAPKAPK5 [nucleoplasm] (Dictyostelium discoideum)
phospho-p-S115 MAPKAPK5 [nucleoplasm] (Plasmodium falciparum)
phospho-p-S115 MAPKAPK5 [nucleoplasm] (Sus scrofa)
phospho-fhkA [nucleoplasm] (Dictyostelium discoideum)
Modified Residues
Name
O-phospho-L-serine at 115
Coordinate
115
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_620777.1
,
NP_003659.2
ZINC - World Drugs
MAPK5_HUMAN
OpenTargets
ENSG00000089022
ZINC - Substances
MAPK5_HUMAN
ZINC target
Q8IW41
ZINC - Biogenic
MAPK5_HUMAN
PRO
Q8IW41
ZINC - Investigational
MAPK5_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000089022-MAPKAPK5
GeneCards
Q8IW41
Ensembl
ENSG00000089022
,
ENSP00000449381
,
ENST00000551404
,
ENST00000550735
,
ENSP00000449667
ZINC - Predictions - Purchasable
MAPK5_HUMAN
HMDB Protein
HMDBP01196
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16659 MAPK6
6
p-3S,T MAPK6 [nucleoplasm]
(R-HSA-5692665)
ub-MAPK6 [cytosol]
(R-HSA-5687000)
MAPK6 [nucleoplasm]
(R-HSA-5692686)
p-S189 MAPK6 [nucleoplasm]
(R-HSA-5687015)
p-S189 MAPK6 [cytosol]
(R-HSA-5687019)
MAPK6 [cytosol]
(R-HSA-5686979)
0.848
7
UniProt:Q15109 AGER
1
AGER [plasma membrane]
(R-HSA-197639)
0.664
6
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