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FOXO3 [cytosol]
Stable Identifier
R-HSA-5687032
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Forkhead box protein O3A, FOXO3_HUMAN, FOXO3A
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
Neurodegenerative Diseases (Homo sapiens)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
CDK5:p25 phosphorylates FOXO3 (Homo sapiens)
FOXO3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
p-T182 MAPKAPK5 phosphorylates FOXO3 (Homo sapiens)
FOXO3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43524 FOXO3
Gene Names
FOXO3, FKHRL1, FOXO3A
Chain
chain:1-673
Reference Genes
BioGPS Gene:2309 FOXO3
COSMIC (genes):FOXO3 FOXO3
CTD Gene:2309 FOXO3
dbSNP Gene:2309 FOXO3
ENSEMBL:ENSG00000118689 FOXO3
HGNC:3821 FOXO3
KEGG:hsa:2309 FOXO3
Monarch:2309 FOXO3
NCBI Gene:2309 FOXO3
OMIM:602681 FOXO3
UCSC:O43524 FOXO3
Reference Transcript
RefSeq:XM_005266868.3 FOXO3
RefSeq:NM_001455.3 FOXO3
RefSeq:NM_201559.2 FOXO3
RefSeq:XM_017010586.1 FOXO3
RefSeq:XM_011535629.2 FOXO3
RefSeq:XM_011535628.2 FOXO3
Other Identifiers
11718890_x_at
11718891_s_at
11718892_s_at
11737906_x_at
11746522_s_at
11746523_x_at
11749812_s_at
11755663_s_at
204131_PM_s_at
204131_s_at
204132_PM_s_at
204132_s_at
210655_PM_s_at
210655_s_at
217399_3p_s_at
217399_PM_s_at
217399_s_at
224889_3p_at
224889_PM_at
224889_at
224891_PM_at
224891_at
2309
2920476
2920477
2920478
2920479
2920480
2920481
2920482
2920483
2920484
2920485
2920486
2920537
2920538
2920541
2920542
2920543
2920556
2920567
2920568
2920570
2920572
2920574
2920575
34740_at
3748537
3748538
3748557
3748558
3748560
3748563
3748564
3748565
3748566
3748567
3748568
3748569
3748570
47893_s_at
49469_at
49651_at
8013307
8121365
A_23_P345575
A_32_P102062
A_33_P3240392
A_33_P3375665
GE54251
GE85764
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001221
GO:0001227
GO:0001228
GO:0001542
GO:0001544
GO:0001547
GO:0001556
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005741
GO:0005759
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006390
GO:0006417
GO:0006915
GO:0008013
GO:0009410
GO:0010508
GO:0012501
GO:0014737
GO:0016020
GO:0019901
GO:0022414
GO:0030330
GO:0030336
GO:0031490
GO:0031667
GO:0032991
GO:0033209
GO:0034246
GO:0034599
GO:0042149
GO:0042593
GO:0042594
GO:0043065
GO:0043226
GO:0043525
GO:0043565
GO:0045591
GO:0045648
GO:0045665
GO:0045893
GO:0045944
GO:0048854
GO:0060070
GO:0070542
GO:0071333
GO:0071386
GO:0071456
GO:0071548
GO:0090090
GO:0090571
GO:0097150
GO:0097192
GO:0140110
GO:1901300
GO:1902895
GO:1903428
GO:1904646
GO:1990090
GO:1990785
GO:1990837
GO:2000177
GO:2000353
GO:2000377
HMNXSV003035668
Hs.14845.0.A2_3p_a_at
Hs.214783.0.S1_3p_at
Hs.214783.0.S1_3p_x_at
Hs.214783.0.S2_3p_at
Hs.274468.0.S1_3p_s_at
ILMN_1681703
ILMN_1687940
ILMN_1712515
ILMN_1844692
PH_hs_0028777
PH_hs_0033951
TC06000868.hg
TC06002977.hg
g4106722_3p_a_at
Participates
as an input of
p-T182 MAPKAPK5 phosphorylates FOXO3 (Homo sapiens)
Cdk5:p25 phosphorylates FOXO3 (Homo sapiens)
CDK5:p25 phosphorylates FOXO3 (Homo sapiens)
Other forms of this molecule
FOXO3 [nucleoplasm]
p-T32,S253,S315-FOXO3 [nucleoplasm]
p-T32,S253,S315-FOXO3 [cytosol]
Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm]
Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix]
FOXO3(?-673) [mitochondrial matrix]
p-S43,S173,S294,S325-FOXO3 [cytosol]
p-S43,S173,S294,S325-FOXO3 [nucleoplasm]
p-S215 FOXO3 [cytosol]
p-S215 FOXO3 [nucleoplasm]
Inferred To
foxo [cytosol]
(Drosophila melanogaster)
FOXO3 [cytosol]
(Bos taurus)
FOXO3 [cytosol]
(Canis familiaris)
FOXO3 [cytosol]
(Gallus gallus)
FOXO3 [cytosol]
(Sus scrofa)
foxo3 [cytosol]
(Xenopus tropicalis)
Foxo3 [cytosol]
(Mus musculus)
Foxo3 [cytosol]
(Rattus norvegicus)
foxo3b [cytosol]
(Danio rerio)
daf-16 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001446.1
,
XP_011533930.1
,
XP_011533931.1
,
NP_963853.1
,
XP_016866075.1
,
XP_005266925.1
OpenTargets
ENSG00000118689
ENSEMBL
ENSP00000385824
,
ENST00000406360
,
ENSP00000339527
,
ENST00000540898
,
ENSP00000446316
,
ENST00000343882
HPA
ENSG00000118689-FOXO3
PRO
O43524
Pharos - Targets
O43524
GlyGen
O43524
PDB
6MNL
,
2LQH
,
7V9B
,
2LQI
,
2K86
,
2UZK
Interactors (29)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.851
6
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.774
6
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.774
6
UniProt:Q13485 SMAD4
20
SMAD4 P356R [cytosol]
(R-HSA-3310988)
SMAD4 K428T [cytosol]
(R-HSA-3311004)
SMAD4 D351del [cytosol]
(R-HSA-3310974)
SMAD4 R361H [cytosol]
(R-HSA-3310984)
SMAD4 P356L [cytosol]
(R-HSA-3310987)
SMAD4 A406T [cytosol]
(R-HSA-3311003)
SMAD4 D351Y [cytosol]
(R-HSA-3310970)
SMAD4 D351H [cytosol]
(R-HSA-3310965)
SMAD4 R361C [cytosol]
(R-HSA-3310983)
SMAD4 D351G [cytosol]
(R-HSA-3310967)
SMAD4 R515T [cytosol]
(R-HSA-3311008)
SMAD4 G352* [cytosol]
(R-HSA-9678445)
SMAD4 S178* [cytosol]
(R-HSA-9675630)
SMAD4 G477* [cytosol]
(R-HSA-9678447)
SMAD4 G473* [cytosol]
(R-HSA-9678440)
SMAD4 S144* [cytosol]
(R-HSA-9675625)
SMAD4 E538* [cytosol]
(R-HSA-9675626)
SMAD4 E390* [cytosol]
(R-HSA-9675620)
SMAD4 S154* [cytosol]
(R-HSA-9675621)
SMAD4 E330* [cytosol]
(R-HSA-9675622)
0.743
9
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.706
5
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.704
5
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.695
5
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
AKT1 [plasma membrane]
(R-HSA-199416)
AKT1 [cytosol]
(R-HSA-58252)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
0.692
3
UniProt:P84022 SMAD3
20
p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-177104)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
SMAD3 [cytosol]
(R-HSA-170855)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
SMAD3 [nucleoplasm]
(R-HSA-206150)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
0.667
5
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.632
7
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.615
3
UniProt:Q92731 ESR2
5
ESR2 [cytosol]
(R-HSA-9020970)
ESR2 [nucleoplasm]
(R-HSA-446165)
Me-PalmS-ESR2 [plasma membrane]
(R-HSA-9637787)
PalmS-ESR2 [plasma membrane]
(R-HSA-9021059)
PalmS-ESR2 [cytosol]
(R-HSA-9020979)
0.591
4
IntAct:EBI-1767788 BIM
0.59
2
UniProt:Q92793 CREBBP
4
CREBBP [nucleoplasm]
(R-HSA-193545)
CREBBP [cytosol]
(R-HSA-9756493)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
0.564
3
UniProt:Q60987 Foxg1
2
Foxg1 [nucleoplasm]
(R-MMU-9022630)
Foxg1 [nucleoplasm]
(R-MMU-9022629)
0.544
5
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.536
2
IntAct:EBI-1657542 ERALPHA
0.527
2
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.524
3
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.499
2
UniProt:O75529 TAF5L
1
TAF5L [nucleoplasm]
(R-HSA-212336)
0.499
2
UniProt:Q96T60 PNKP
1
PNKP [nucleoplasm]
(R-HSA-5649651)
0.499
2
UniProt:Q92974 ARHGEF2
1
ARHGEF2 [cytosol]
(R-HSA-195101)
0.499
2
UniProt:P85037 FOXK1
1
FOXK1 [nucleoplasm]
(R-HSA-5689673)
0.499
2
UniProt:P30260 CDC27
2
CDC27 [nucleoplasm]
(R-HSA-174175)
CDC27 [cytosol]
(R-HSA-174073)
0.499
2
UniProt:P28749 RBL1
2
RBL1 [nucleoplasm]
(R-HSA-389104)
p-T369,S640,S964,S975-RBL1 [nucleoplasm]
(R-HSA-1226085)
0.499
3
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.471
3
UniProt:P30153 PPP2R1A
2
PPP2R1A [cytosol]
(R-HSA-165982)
PPP2R1A [nucleoplasm]
(R-HSA-165968)
0.462
2
IntAct:EBI-2891650 CDKN1B
0.462
2
IntAct:EBI-2678752 ANDR
0.462
2
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