MAPK6 is ubiquitinated at the N-terminal

Stable Identifier
R-HSA-5687081
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MAPK6 is an unstable protein that is constitutively degraded by the ubiquitin-proteasome system. Degradation is promoted by two destabilization regions in the N-terminal region of MAPK6 which are required for the conjugation of ubiquitin to the free amino-terminal by an unknown ligase (Coulombe et al, 2003; Coulombe et al, 2004). Although in this reaction ubiquitination is depicted as occuring in the cytosol, it may also occur in the nucleus.

Literature References
PubMed ID Title Journal Year
12808096 Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation

Coulombe, P, Rodier, G, Pelletier, S, Pellerin, J, Meloche, S

Mol. Cell. Biol. 2003
15226418 N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome

Coulombe, P, Rodier, G, Bonneil, E, Thibault, P, Meloche, S

Mol. Cell. Biol. 2004
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Catalyst Activity
Title
ubiquitin protein ligase activity of unknown ubiquitin ligase [cytosol]
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Activity
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