MYC binds MAPKAPK5 gene

Stable Identifier
R-HSA-5687083
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MYC binds MAPKAPK5 gene
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

MYC binds to consensus sites in the MAPKAPK5 gene promoter as assessed by ChIP (Kress et al, 2011). Although not depicted here and not experimentally validated in this context, MYC likely binds the promoter in the context of a MYC:MAX heterodimer.

Literature References
PubMed ID Title Journal Year
21329882 The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis

Kress, TR, Cannell, IG, Brenkman, AB, Samans, B, Gaestel, M, Roepman, P, Burgering, BM, Bushell, M, Rosenwald, A, Eilers, M

Mol. Cell 2011
Participants
Input
Output
Participant Of
hasEvent
Authored
Rothfels, K  (2015-03-30)
Reviewed
Moens, U  (2015-04-24)
Seternes, OM  (2015-05-05)
Mathien, S  (2015-05-12)
Meloche, S  (2015-05-12)
Soulez, M  (2015-05-12)
Created
Rothfels, K  (2015-04-06)
Cite Us!