MYC binds MAPKAPK5 gene

Stable Identifier
R-HSA-5687083
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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MYC binds MAPKAPK5 gene
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MYC binds to consensus sites in the MAPKAPK5 gene promoter as assessed by ChIP (Kress et al, 2011). Although not depicted here and not experimentally validated in this context, MYC likely binds the promoter in the context of a MYC:MAX heterodimer.

Literature References
PubMed ID Title Journal Year
21329882 The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis

Kress, TR, Cannell, IG, Brenkman, AB, Samans, B, Gaestel, M, Roepman, P, Burgering, BM, Bushell, M, Rosenwald, A, Eilers, M

Mol. Cell 2011
Participants
Input
Output
Participant Of
hasEvent
Authored
Rothfels, K  (2015-03-30)
Reviewed
Moens, U  (2015-04-24)
Seternes, OM  (2015-05-05)
Mathien, S  (2015-05-12)
Meloche, S  (2015-05-12)
Soulez, M  (2015-05-12)
Created
Rothfels, K  (2015-04-06)