p-S MAPK6 phosphorylates NCOA3

Stable Identifier
R-HSA-5687090
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MAPK6 is proposed to phosphorylate NCOA3 at serine 857. This phosphorylation is required for NCOA3 to interact with the transcription factor ETV4 (also known as PEA3). Together, ETV4 and NCOA3 bind to the promoters and regulate the expression of metalloprotease genes such as MMP2 and MMP10 and in this way contribute to cell motility and invasiveness in lung cancer (Long et al, 2012; Qin et al, 2008; Yan et al, 2008; Li et al, 2008; reviewed in Kostenko et al, 2012).

Literature References
PubMed ID Title Journal Year
18593949 Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression

Yan, J, Erdem, H, Li, R, Cai, Y, Ayala, G, Ittmann, M, Yu-Lee, LY, Tsai, SY, Tsai, MJ

Cancer Res. 2008
22800433 Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5

Kostenko, S, Dumitriu, G, Moens, U

J Mol Signal 2012
22505454 ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion

Long, W, Foulds, CE, Qin, J, Qin, J, Liu, J, Ding, C, Lonard, DM, Solis, LM, Wistuba, II, Tsai, SY, Tsai, MJ, O'Malley, BW

J. Clin. Invest. 2012
18162290 Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression

Li, LB, Louie, MC, Chen, HW, Zou, JX

Cancer Lett. 2008
18644862 The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression

Qin, L, Liao, L, Redmond, A, Young, L, Yuan, Y, Chen, H, O'Malley, BW, Xu, J

Mol. Cell. Biol. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S189 MAPK6 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created