p-S857 NCOA3 binds ETV4

Stable Identifier
R-HSA-5687097
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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NCOA3 interacts with ETV4 (also known as PEA3) in a manner that depends on S857 phosphorylation (Long et al, 2012). ETV4 and NCOA3 coactivate expression of a number of MMP genes, which play roles in cell motility and invasiveness in a subset of lung carcinomas (Long et al, 2012; Qin et al, 2008; Yan et al, 2008).

Literature References
PubMed ID Title Journal Year
22505454 ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion

Long, W, Foulds, CE, Qin, J, Qin, J, Liu, J, Ding, C, Lonard, DM, Solis, LM, Wistuba, II, Tsai, SY, Tsai, MJ, O'Malley, BW

J. Clin. Invest. 2012
18593949 Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression

Yan, J, Erdem, H, Li, R, Cai, Y, Ayala, G, Ittmann, M, Yu-Lee, LY, Tsai, SY, Tsai, MJ

Cancer Res. 2008
18644862 The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression

Qin, L, Liao, L, Redmond, A, Young, L, Yuan, Y, Chen, H, O'Malley, BW, Xu, J

Mol. Cell. Biol. 2008
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