MAPK6-dependent phosphorylation of NCOA3 S857 promotes its interaction with the transcription factor ETV4 and increases the occupancy at promoters of the MMP2 and 10 genes in vivo as assessed by ChIP (Long et al, 2012; Qin et al, 2008; Yan et al, 2008). MMP gene expression is associated with invasiveness in lung and breast cancer, and MAPK6 is highly expressed in a subset of human lung carcinomas (Long et al, 2012; Qin et al, 2008; Yan et al, 2008; Li et al, 2008; reviewed in Kostenko et al, 2012).
Yan, J, Erdem, H, Li, R, Cai, Y, Ayala, G, Ittmann, M, Yu-Lee, LY, Tsai, SY, Tsai, MJ
Kostenko, S, Dumitriu, G, Moens, U
Long, W, Foulds, CE, Qin, J, Qin, J, Liu, J, Ding, C, Lonard, DM, Solis, LM, Wistuba, II, Tsai, SY, Tsai, MJ, O'Malley, BW
Qin, L, Liao, L, Redmond, A, Young, L, Yuan, Y, Chen, H, O'Malley, BW, Xu, J
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