p-S857 NCOA3:ETV4 bind MMP2 and MMP10 promoter

Stable Identifier
R-HSA-5687099
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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p-S857 NCOA3:ETV4 bind MMP2 and MMP10 promoter
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MAPK6-dependent phosphorylation of NCOA3 S857 promotes its interaction with the transcription factor ETV4 and increases the occupancy at promoters of the MMP2 and 10 genes in vivo as assessed by ChIP (Long et al, 2012; Qin et al, 2008; Yan et al, 2008). MMP gene expression is associated with invasiveness in lung and breast cancer, and MAPK6 is highly expressed in a subset of human lung carcinomas (Long et al, 2012; Qin et al, 2008; Yan et al, 2008; Li et al, 2008; reviewed in Kostenko et al, 2012).

Literature References
PubMed ID Title Journal Year
18593949 Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression

Yan, J, Erdem, H, Li, R, Cai, Y, Ayala, G, Ittmann, M, Yu-Lee, LY, Tsai, SY, Tsai, MJ

Cancer Res. 2008
22800433 Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5

Kostenko, S, Dumitriu, G, Moens, U

J Mol Signal 2012
22505454 ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion

Long, W, Foulds, CE, Qin, J, Qin, J, Liu, J, Ding, C, Lonard, DM, Solis, LM, Wistuba, II, Tsai, SY, Tsai, MJ, O'Malley, BW

J. Clin. Invest. 2012
18644862 The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression

Qin, L, Liao, L, Redmond, A, Young, L, Yuan, Y, Chen, H, O'Malley, BW, Xu, J

Mol. Cell. Biol. 2008
Participants
Input
Output
Participant Of
hasEvent
Authored
Rothfels, K  (2015-04-03)
Reviewed
Moens, U  (2015-04-24)
Seternes, OM  (2015-05-05)
Mathien, S  (2015-05-12)
Meloche, S  (2015-05-12)
Soulez, M  (2015-05-12)
Created
Rothfels, K  (2015-04-06)