Reactome | p-T182 MAPKAPK5 phosphorylates FOXO3

p-T182 MAPKAPK5 phosphorylates FOXO3

Stable Identifier

R-HSA-5687101

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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Activated MAPKAPK5 phosphorylates FOXO3 at serine 215, promoting its activation and translocation to the nucleus. In the nucleus, FOXO3 promotes the expression of miR-34B and C, which in turn represses translation of MYC RNA (Kress et al, 2011; reviewed in Myant and Sansom, 2011; Kostenko et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
21329882	The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis Kress, TR, Cannell, IG, Brenkman, AB, Samans, B, Gaestel, M, Roepman, P, Burgering, BM, Bushell, M, Rosenwald, A, Eilers, M	Mol. Cell	2011
22800433	Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5 Kostenko, S, Dumitriu, G, Moens, U	J Mol Signal	2012
21329875	More, more, more: downregulation of a MK5-FoxO3a-mir34b/c pathway further increases c-Myc levels in colorectal cancer Myant, K, Sansom, OJ	Mol. Cell	2011