Activated MAPKAPK5 phosphorylates FOXO3 at serine 215, promoting its activation and translocation to the nucleus. In the nucleus, FOXO3 promotes the expression of miR-34B and C, which in turn represses translation of MYC RNA (Kress et al, 2011; reviewed in Myant and Sansom, 2011; Kostenko et al, 2012).
Kress, TR, Cannell, IG, Brenkman, AB, Samans, B, Gaestel, M, Roepman, P, Burgering, BM, Bushell, M, Rosenwald, A, Eilers, M
Kostenko, S, Dumitriu, G, Moens, U
Myant, K, Sansom, OJ
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