Reactome | IGF2BP1 represses translation of MAPK4 mRNA

IGF2BP1 represses translation of MAPK4 mRNA

Stable Identifier

R-HSA-5687105

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

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IGF2BP1 represses translation of MAPK4 mRNA

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Binding of IGF2BP1 to the 3' UTR of MAPK4 mRNA inhibits its translation and in this way antagonizes the MAPKAPK5-dependent phosphorylation of HSBP1 (Stohr et al, 2012; Kostenko et al, 2009a; reviewed in Kostenko et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
19166925	PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5 Kostenko, S, Johannessen, M, Moens, U	Cell. Signal.	2009
22800433	Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5 Kostenko, S, Dumitriu, G, Moens, U	J Mol Signal	2012
22279049	IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling Stöhr, N, Köhn, M, Lederer, M, Glass, M, Reinke, C, Singer, RH, Hüttelmaier, S	Genes Dev.	2012