Despite differences in their overall cellular distribution (MAPK6 is found in both the nucleus and the cytosol, while MAPK4 is predominantly found in the cytosol), both MAPK4 and 6 shuttle between the cytosol and the nucleus. Nuclear import of both proteins occurs through an active temperature sensitive pathway, while nuclear export depends on XPO1 (Aberg et al, 2006; Julien et al, 2003).
Julien, C, Coulombe, P, Meloche, S
Aberg, E, Perander, M, Johansen, B, Julien, C, Meloche, S, Keyse, SM, Seternes, OM
© 2020 Reactome
