Reactome | MAPK6 is degraded by the 26S proteasome

MAPK6 is degraded by the 26S proteasome

Stable Identifier

R-HSA-5687112

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

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MAPK6 is a short-lived protein with a half-life of 30 minutes in proliferating cells. Turnover is promoted by the conjugation of ubiquitin to the free amino terminal by an unknown ligase and subsequent degradation by the 26 S proteasome (Coulombe et al, 2003; Coulombe et al, 2004). Ubiquitination and degradation of MAPK6 may also occur in the nucleus as well as the cytosol.

Literature References

PubMed ID	Title	Journal	Year
12808096	Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation Coulombe, P, Rodier, G, Pelletier, S, Pellerin, J, Meloche, S	Mol. Cell. Biol.	2003
15226418	N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome Coulombe, P, Rodier, G, Bonneil, E, Thibault, P, Meloche, S	Mol. Cell. Biol.	2004