MYC mRNA translation is negatively regulated by miR-34B and C

Stable Identifier
R-HSA-5687113
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
cytosol
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MYC mRNA translation is negatively regulated by miR-34B and C
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Translation of MYC mRNA is negatively regulated by miR-34B and C microRNAs (Kress et al, 2011). miR-34 miRNAs bind and cause degradation of MYC mRNA, resulting in decreased level of MYC protein product (reviewed in Myant and Sansom, 2011; Kostenko et al, 2012).

Literature References
PubMed ID Title Journal Year
21329882 The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis

Kress, TR, Cannell, IG, Brenkman, AB, Samans, B, Gaestel, M, Roepman, P, Burgering, BM, Bushell, M, Rosenwald, A, Eilers, M

Mol. Cell 2011
22800433 Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5

Kostenko, S, Dumitriu, G, Moens, U

J Mol Signal 2012
21329875 More, more, more: downregulation of a MK5-FoxO3a-mir34b/c pathway further increases c-Myc levels in colorectal cancer

Myant, K, Sansom, OJ

Mol. Cell 2011
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Authored
Rothfels, K  (2015-03-30)
Reviewed
Moens, U  (2015-04-24)
Seternes, OM  (2015-05-05)
Mathien, S  (2015-05-12)
Meloche, S  (2015-05-12)
Soulez, M  (2015-05-12)
Created
Rothfels, K  (2015-04-06)