MYC positively regulates MAPKAPK5 gene expression

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R-HSA-5687115
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
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MYC binds to consensus sites in the MAPKAPK5 promoter to promote transcription. This completes a negative feedback loop controlling MYC expression, as MAPKAPK5 itself negatively regulates MYC protein levels through FOXO3 and miR-34B and C (Kress et al, 2011). This pathway is disrupted in colorectal cancer, leading to aberrant cellular proliferation (Kress et al, 2011; reviewed in Myant and Sansom, 2011; Kostenko et al, 2012).

Literature References
PubMed ID Title Journal Year
21329882 The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis

Kress, TR, Cannell, IG, Brenkman, AB, Samans, B, Gaestel, M, Roepman, P, Burgering, BM, Bushell, M, Rosenwald, A, Eilers, M

Mol. Cell 2011
22800433 Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5

Kostenko, S, Dumitriu, G, Moens, U

J Mol Signal 2012
21329875 More, more, more: downregulation of a MK5-FoxO3a-mir34b/c pathway further increases c-Myc levels in colorectal cancer

Myant, K, Sansom, OJ

Mol. Cell 2011
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