Binding of MAPK6 or 4 to MAPKAPK5 promotes its redistribution to the cytosol. This depends on a functional protein-protein interaction interface between the two proteins. Cytoplasmic translocation of MAPKAPK5 occurs even in the presence of catalytically inactive MAPK6 or MAPK6 and vice versa, MAPK6 and MAPK4 still provoke nuclear exclusion of kinase inactive MAPKAPK5 (Aberg et al, 2006; Seternes et al, 2004; Kant et al, 2006; reviewed in Kostenko et al, 2012). Phosphorylation of MAPK6 or MAPK4 at S189 or S186 respectively, is required for binding and translocation of MAPKAPK5 to the cytosol (Perander et al, 2008; Deleris et al, 2008; De La Mota-Peynado et al, 2011).
Kant, S, Schumacher, S, Singh, MK, Kispert, A, Kotlyarov, A, Gaestel, M
Kostenko, S, Dumitriu, G, Moens, U
Aberg, E, Perander, M, Johansen, B, Julien, C, Meloche, S, Keyse, SM, Seternes, OM
De la Mota-Peynado, A, Chernoff, J, Beeser, A
Déléris, P, Rousseau, J, Coulombe, P, Rodier, G, Tanguay, PL, Meloche, S
Seternes, OM, Mikalsen, T, Johansen, B, Michaelsen, E, Armstrong, CG, Morrice, NA, Turgeon, B, Meloche, S, Moens, U, Keyse, SM
Perander, M, Aberg, E, Johansen, B, Dreyer, B, Guldvik, IJ, Outzen, H, Keyse, SM, Seternes, OM
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