Reactome | p-S115 MAPKAPK5 translocates to the cytosol

p-S115 MAPKAPK5 translocates to the cytosol

Stable Identifier

R-HSA-5687123

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

p-S115 MAPKAPK5 translocates to the cytosol

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PKA-mediated phosphorylation of serine 115 promotes the translocation of MAPKAPK5 to the cytosol (Kostenko et al, 2011a; Gerits et al, 2007).

Literature References

PubMed ID	Title	Journal	Year
17947239	Modulation of F-actin rearrangement by the cyclic AMP/cAMP-dependent protein kinase (PKA) pathway is mediated by MAPK-activated protein kinase 5 and requires PKA-induced nuclear export of MK5 Gerits, N, Mikalsen, T, Kostenko, S, Shiryaev, A, Johannessen, M, Moens, U	J. Biol. Chem.	2007
20734105	Serine residue 115 of MAPK-activated protein kinase MK5 is crucial for its PKA-regulated nuclear export and biological function Kostenko, S, Shiryaev, A, Gerits, N, Dumitriu, G, Klenow, H, Johannessen, M, Moens, U	Cell. Mol. Life Sci.	2011