p-S115 MAPKAPK5 translocates to the cytosol

Stable Identifier
R-HSA-5687123
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
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PKA-mediated phosphorylation of serine 115 promotes the translocation of MAPKAPK5 to the cytosol (Kostenko et al, 2011a; Gerits et al, 2007).

Literature References
PubMed ID Title Journal Year
17947239 Modulation of F-actin rearrangement by the cyclic AMP/cAMP-dependent protein kinase (PKA) pathway is mediated by MAPK-activated protein kinase 5 and requires PKA-induced nuclear export of MK5

Gerits, N, Mikalsen, T, Kostenko, S, Shiryaev, A, Johannessen, M, Moens, U

J. Biol. Chem. 2007
20734105 Serine residue 115 of MAPK-activated protein kinase MK5 is crucial for its PKA-regulated nuclear export and biological function

Kostenko, S, Shiryaev, A, Gerits, N, Dumitriu, G, Klenow, H, Johannessen, M, Moens, U

Cell. Mol. Life Sci. 2011
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