p-S215 FOXO3 translocates to the nucleus

Stable Identifier
R-HSA-5687126
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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MAPKAPK5-dependent phosphorylation of FOXO3 promotes its nuclear localization (Kress et al, 2011). In the nucleus, FOXO3 promotes expression of miR-34B and C and thereby downregulates expression of c-MYC RNA (Kress et al, 2011; reviewed in Myant and Sansom, 2011; Kostenko et al, 2012).

Literature References
PubMed ID Title Journal Year
21329882 The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis

Kress, TR, Cannell, IG, Brenkman, AB, Samans, B, Gaestel, M, Roepman, P, Burgering, BM, Bushell, M, Rosenwald, A, Eilers, M

Mol. Cell 2011
22800433 Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5

Kostenko, S, Dumitriu, G, Moens, U

J Mol Signal 2012
21329875 More, more, more: downregulation of a MK5-FoxO3a-mir34b/c pathway further increases c-Myc levels in colorectal cancer

Myant, K, Sansom, OJ

Mol. Cell 2011
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