Reactome | MRN and RBBP8 resect DNA DSBs in MMEJ

MRN and RBBP8 resect DNA DSBs in MMEJ

Stable Identifier

R-HSA-5687464

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The complex of MRN (MRE11A:RAD50:NBN) and RBBP8 (CtIP) performs a limited resection of DNA double strand breaks (DSBs) in the process of microhomology-mediated end joining (MMEJ) (Yun et al. 2009). ATM activation inhibits MMEJ-related resection of DNA DSBs by MRN, possibly through MRN phosphorylation (Rahal et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20647759	ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining Tainer, JA, Henricksen, LA, Dixon, K, Williams, RS, Rahal, EA, Li, Y	Cell Cycle	2010
19357644	CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle Yun, MH, Hiom, K	Nature	2009