Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
p-S990,Ac-K1249-BRIP1 [nucleoplasm]
Stable Identifier
R-HSA-5687710
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-S990,Ac-K1249-FANCJ, p-S990,Ac-K1249-BACH1
Locations in the PathwayBrowser for interactor UniProt:P40692
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
Resolution of D-Loop Structures (Homo sapiens)
Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
BLM mediates dissolution of double Holliday junction (Homo sapiens)
p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) (Homo sapiens)
D-loop dissociation and strand annealing (Homo sapiens)
p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
HDR through Single Strand Annealing (SSA) (Homo sapiens)
ERCC1:XPF cleaves flaps generated by SSA (Homo sapiens)
p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
Processing of DNA double-strand break ends (Homo sapiens)
EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Homo sapiens)
p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BX63 BRIP1
Gene Names
BRIP1, BACH1, FANCJ
Chain
chain:1-1249
Reference Genes
BioGPS Gene:83990 BRIP1
COSMIC (genes):BRIP1 BRIP1
CTD Gene:83990 BRIP1
dbSNP Gene:83990 BRIP1
ENSEMBL:ENSG00000136492 BRIP1
ENSEMBL_homo_sapiens_GENE:ENSG00000136492.10 BRIP1
HGNC:20473 BRIP1
KEGG Gene (Homo sapiens):83990 BRIP1
Monarch:83990 BRIP1
NCBI Gene:83990 BRIP1
OMIM:605882 BRIP1
UCSC:Q9BX63 BRIP1
Reference Transcript
RefSeq:NM_032043.2 BRIP1
Other Identifiers
11736601_at
11736602_at
16847432
221703_PM_at
221703_at
235609_PM_at
235609_at
3765583
3765584
3765585
3765586
3765587
3765588
3765589
3765590
3765591
3765598
3765599
3765605
3765606
3765608
3765610
3765611
3765612
3765614
3765616
3765617
3765619
3765623
3765625
3765627
3765628
3765629
3765630
3765631
3765632
3765634
3765635
3765636
55362_at
62361_at
74375_at
8017262
83990
A_23_P15844
A_24_P410468
GE83302
GO:0000077
GO:0000166
GO:0003676
GO:0003677
GO:0003678
GO:0003682
GO:0003724
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005634
GO:0005635
GO:0005654
GO:0005737
GO:0006139
GO:0006281
GO:0006289
GO:0006302
GO:0006310
GO:0006351
GO:0006355
GO:0006357
GO:0006974
GO:0007059
GO:0007129
GO:0007283
GO:0007284
GO:0007286
GO:0008285
GO:0008584
GO:0009636
GO:0010629
GO:0010705
GO:0016787
GO:0016818
GO:0016887
GO:0022414
GO:0023052
GO:0030154
GO:0031965
GO:0032508
GO:0035825
GO:0043139
GO:0043226
GO:0046872
GO:0048856
GO:0051026
GO:0051276
GO:0051536
GO:0051539
GO:0070532
GO:0071295
GO:0071456
GO:0072520
GO:0140013
GO:0140097
GO:0140098
GO:0140657
GO:1904385
GO:1990918
HMNXSV003015180
Hs.87507.0.A1_3p_at
ILMN_1760757
TC17001769.hg
g13661818_3p_at
Participates
as a component of
Defective 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2 [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:BRCA2 mutants (PALB2 binding):SEM1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
as an output of
ERCC1:XPF cleaves flaps generated by SSA (Homo sapiens)
BLM mediates dissolution of double Holliday junction (Homo sapiens)
Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
D-loop dissociation and strand annealing (Homo sapiens)
as an input of
EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Homo sapiens)
Other forms of this molecule
BRIP1 [cytosol]
Inferred To
phospho-dog-1 [nucleoplasm]
(Caenorhabditis elegans)
phospho-brip1 [nucleoplasm]
(Xenopus tropicalis)
Ghost homologue of p-S990,Ac-K1249-BRIP1 [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of p-S990,Ac-K1249-BRIP1 [nucleoplasm]
(Schizosaccharomyces pombe)
phospho-Brip1 [nucleoplasm]
(Rattus norvegicus)
phospho-p-S990,Ac-K1249-BRIP1 [nucleoplasm]
(Gallus gallus)
phospho-p-S990,Ac-K1249-BRIP1 [nucleoplasm]
(Mus musculus)
phospho-BRIP1 [nucleoplasm]
(Bos taurus)
phospho-BRIP1 [nucleoplasm]
(Canis familiaris)
phospho-BRIP1 [nucleoplasm]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at 990
Coordinate
990
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
N6-acetyl-L-lysine at 1249
Coordinate
1249
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Cross References
RefSeq
NP_114432.2
OpenTargets
ENSG00000136492
HPA
ENSG00000136492-BRIP1
GeneCards
Q9BX63
Ensembl
ENST00000259008
,
ENSP00000508303
,
ENSP00000464654
,
ENSG00000136492
,
ENST00000683039
,
ENSP00000259008
,
ENST00000577598
,
ENST00000682453
,
ENSP00000506943
PRO
Q9BX63
Pharos - Targets
Q9BX63
Orphanet
15379
HMDB Protein
HMDBP11734
PDB
1T15
,
3AL3
,
1T29
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P38398 BRCA1
20
polySUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
monoSUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
BRCA1 M1411T [nucleoplasm]
(R-HSA-9702140)
BRCA1 M1400V [nucleoplasm]
(R-HSA-9701202)
BRCA1 L1407P [nucleoplasm]
(R-HSA-9702135)
BRCA1 Y777* [nucleoplasm]
(R-HSA-9702765)
BRCA1 S1009* [nucleoplasm]
(R-HSA-9702755)
BRCA1 P724Lfs*12 [nucleoplasm]
(R-HSA-9703778)
BRCA1 S451* [nucleoplasm]
(R-HSA-9702754)
BRCA1 S864* [nucleoplasm]
(R-HSA-9702752)
BRCA1 P897Kfs*5 [nucleoplasm]
(R-HSA-9703782)
BRCA1 N555Kfs*17 [nucleoplasm]
(R-HSA-9703781)
BRCA1 Y1127Sfs*6 [nucleoplasm]
(R-HSA-9703780)
BRCA1 S886Cfs*16 [nucleoplasm]
(R-HSA-9703802)
BRCA1 V83Cfs*2 [nucleoplasm]
(R-HSA-9703800)
BRCA1 T464Pfs*11 [nucleoplasm]
(R-HSA-9703807)
BRCA1 G813Dfs*2 [nucleoplasm]
(R-HSA-9703549)
BRCA1 V340Gfs*6 [nucleoplasm]
(R-HSA-9703804)
BRCA1 Y655* [nucleoplasm]
(R-HSA-9702769)
BRCA1 W372* [nucleoplasm]
(R-HSA-9702768)
0.979
33
UniProt:P40692 MLH1
3
MLH1 S252* [nucleoplasm]
(R-HSA-5444526)
MLH1 H329P [nucleoplasm]
(R-HSA-5444512)
MLH1 [nucleoplasm]
(R-HSA-912495)
0.886
18
UniProt:P54278 PMS2
3
PMS2 R134* [nucleoplasm]
(R-HSA-5632982)
PMS2 R628* [nucleoplasm]
(R-HSA-5632980)
PMS2 [nucleoplasm]
(R-HSA-5357527)
0.69
5
UniProt:P54132 BLM
2
4SUMO2,3-BLM [nucleoplasm]
(R-HSA-4568883)
BLM [nucleoplasm]
(R-HSA-174881)
0.672
16
UniProt:Q96T76 MMS19
1
MMS19 [cytosol]
(R-HSA-2161121)
0.577
4
UniProt:Q9BPX1 HSD17B14
1
HSD17B14 [cytosol]
(R-HSA-6810587)
0.556
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text