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PPP4C:PPP4R2 dephosphorylates RPA2

Stable Identifier
R-HSA-5687758
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The protein serine/threonine phosphatase complex composed of a catalytic subunit PPP4C (PP4C) and a regulatory subunit PPP4R2 (PP4R2) dephosphorylates serine S33 of the RPA2 subunit of the RPA heterotrimer. By regulating the availability of unphosphorylated RPA2, PPP4C:PPP4R2 phosphatase regulates the progression of the homologous recombination repair of DNA double strand breaks and the duration of ATR checkpoint signaling (Lee et al. 2010).

Literature References
PubMed ID Title Journal Year
20154705 A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination Nat. Struct. Mol. Biol. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine phosphatase activity of PPP4C:PPP4R2 [nucleoplasm]
Physical Entity
Activity
Orthologous Events