Reactome | TFG [cytosol]

TFG [cytosol]

Stable Identifier

R-HSA-5688159

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)
        
        SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)
        
        Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)
      - SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)
      - Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92734 TFG

Gene Names

TFG

Chain

chain:1-400

Reference Genes

BioGPS Gene:10342 TFG

COSMIC (genes):TFG TFG

CTD Gene:10342 TFG

dbSNP Gene:10342 TFG

ENSEMBL:ENSG00000114354 TFG

HGNC:11758 TFG

KEGG Gene (Homo sapiens):10342 TFG

Monarch:10342 TFG

NCBI Gene:10342 TFG

OMIM:602498 TFG

UCSC:Q92734 TFG

Reference Transcript

Other Identifiers

0003140022

0101190100

10342

11715598_at

16943375

217839_at

2633774

2633775

2633776

2633780

2633781

2633782

2633784

2633787

2633789

2633791

2633798

2633802

2633805

2633806

2633807

2633809

8081316

88110_at

A_14_P136435

A_23_P29517

GE61614

GO:0000139

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005783

GO:0005794

GO:0005829

GO:0006810

GO:0006888

GO:0007165

GO:0008150

GO:0016192

GO:0022607

GO:0042802

GO:0043123

GO:0043226

GO:0043231

GO:0048208

GO:0061024

GO:0065003

GO:0070971

ILMN_1779213

ILMN_1812474

ILMN_2341815

PH_hs_0026111

TC03000512.hg

g5174718_3p_at

Participant Of

hasComponent

TFG hexamer [cytosol]

Inferred To

Ghost homologue of TFG [cytosol] (Dictyostelium discoideum)

Ghost homologue of TFG [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of TFG [cytosol] (Schizosaccharomyces pombe)

TFG [cytosol] (Bos taurus)

TFG [cytosol] (Canis familiaris)

TFG [cytosol] (Gallus gallus)

TFG [cytosol] (Sus scrofa)

Tfg [cytosol] (Mus musculus)

Tfg [cytosol] (Rattus norvegicus)

tfg [cytosol] (Danio rerio)

tfg [cytosol] (Xenopus tropicalis)

tfg-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

XP_016861017.1, XP_016861016.1, NP_006061.2, XP_016861019.1, XP_016861018.1, NP_001182408.1, NP_001182407.1, NP_001007566.1, XP_006713535.1, XP_005247123.1, XP_011510636.1, XP_006713536.1

OpenTargets

ENSG00000114354

GeneCards

Q92734

HPA

ENSG00000114354-TFG

Ensembl

ENST00000240851, ENSP00000417952, ENSP00000419960, ENST00000615993, ENST00000418917, ENSG00000114354, ENSP00000479269, ENSP00000479981, ENST00000476228, ENSP00000240851, ENST00000490574, ENST00000620299, ENSP00000397182

PRO

Q92734

Orphanet

15604

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.718	8
UniProt:Q8TDS5 OXER1	1	OXER1 [plasma membrane] (R-HSA-416425)	0.556	3
UniProt:P52597 HNRNPF	2	HNRNPF [plasma membrane] (R-HSA-8950714) HNRNPF [nucleoplasm] (R-HSA-71937)	0.556	3
UniProt:Q71SY5 MED25	1	MED25 [nucleoplasm] (R-HSA-212414)	0.556	3
UniProt:O14964 HGS	2	HGS [phagocytic vesicle lumen] (R-HSA-9635660) HGS [cytosol] (R-HSA-182954)	0.556	3
UniProt:O75593 FOXH1	1	FOXH1 [nucleoplasm] (R-HSA-1225914)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.547	2