SIRT4 transfers ADPRib to GLUD

Stable Identifier
R-HSA-5688276
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Sirtuin 4 (SIRT4) is a mitochondrial ADP-ribosyltransferase and deacetylase. It uses NAD+ to ADP-ribosylate glutamate dehydrogenase (GLUD), reducing its enzyme activity by at least 50%, leading to reduced insulin secretion in pancreatic beta cells (Haigis et al. 2006, Ahuja et al. 2007).

Literature References
PubMed ID Title Journal Year
17715127 Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase

Ahuja, N, Schwer, B, Carobbio, S, Waltregny, D, North, BJ, Castronovo, V, Maechler, P, Verdin, E

J. Biol. Chem. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
NAD+ ADP-ribosyltransferase activity of SIRT4:Zn2+ [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created