SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2

Stable Identifier
R-HSA-5688289
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Sirtuin 3 (SIRT3) is the most extensively studied of the mitochondrial sirtuins. It deacetylates and thereby activates Acetyl-CoA synthetase 2 (ACCS2), Glutamate dehydrogenase (GLUD), Isocitrate dehydrogenase 2 (IDH2) and Superoxide dismutase 2 (SOD2) (Schwer et al. 2006, Lombard et al. 2007, Schlicker et al. 2008, Tao et al. 2010).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
NAD-dependent protein deacetylase activity of SIRT3(?-399):Zn2+ [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events