SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2

Stable Identifier
R-HSA-5688289
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Sirtuin 3 (SIRT3) is the most extensively studied of the mitochondrial sirtuins. It deacetylates and thereby activates Acetyl-CoA synthetase 2 (ACCS2), Glutamate dehydrogenase (GLUD), Isocitrate dehydrogenase 2 (IDH2) and Superoxide dismutase 2 (SOD2) (Schwer et al. 2006, Lombard et al. 2007, Schlicker et al. 2008, Tao et al. 2010).

Literature References
PubMed ID Title Journal Year
16788062 Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

Schwer, B, Bunkenborg, J, Verdin, RO, Andersen, JS, Verdin, E

Proc Natl Acad Sci U S A 2006
17923681 Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

Lombard, DB, Alt, FW, Cheng, HL, Bunkenborg, J, Streeper, RS, Mostoslavsky, R, Kim, J, Yancopoulos, G, Valenzuela, D, Murphy, A, Yang, Y, Chen, Y, Hirschey, MD, Bronson, RT, Haigis, M, Guarente, LP, Farese, RV, Weissman, S, Verdin, E, Schwer, B

Mol. Cell. Biol. 2007
18680753 Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5

Schlicker, C, Gertz, M, Papatheodorou, P, Kachholz, B, Becker, CF, Steegborn, C

J. Mol. Biol. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
NAD-dependent protein deacetylase activity of SIRT3(?-399):Zn2+ [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed