SIRT5 deacetylates Cytochrome C

Stable Identifier
R-HSA-5688294
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial intermembrane space
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SIRT5 deacetylates Cytochrome C
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Sirtuin 5 has been shown to deacetylate Cytochrome C in the the mitochondrial intermembrane space (Schlicker et al. 2008). The functional significance of this is unknown (Bao & Sack 2010).
Literature References
PubMed ID Title Journal Year
18680753 Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5

Papatheodorou, P, Schlicker, C, Becker, CF, Steegborn, C, Gertz, M, Kachholz, B

J. Mol. Biol. 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

NAD-dependent protein deacetylase activity of SIRT5:Zn2+ [mitochondrial intermembrane space]

Physical Entity
SIRT5:Zn2+ [mitochondrial intermembrane space] (Homo sapiens)
Activity
NAD-dependent protein deacetylase activity (GO:0034979)
Orthologous Events
SIRT5 deacetylates Cytochrome C (Bos taurus)
SIRT5 deacetylates Cytochrome C (Danio rerio)
SIRT5 deacetylates Cytochrome C (Dictyostelium discoideum)
SIRT5 deacetylates Cytochrome C (Gallus gallus)
SIRT5 deacetylates Cytochrome C (Mus musculus)
SIRT5 deacetylates Cytochrome C (Plasmodium falciparum)
SIRT5 deacetylates Cytochrome C (Rattus norvegicus)
SIRT5 deacetylates Cytochrome C (Sus scrofa)
SIRT5 deacetylates Cytochrome C (Xenopus tropicalis)
Authored
Jupe, S  (2015-04-15)
Reviewed
Haigis, M  (2017-02-01)
Created
Jupe, S  (2015-04-15)
Cite Us!