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TRIM50 [cytosol]
Stable Identifier
R-HSA-5688976
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase TRIM50 ecNumber6.3.2.-/ecNumber, TRI50_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM50 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM50 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM50 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM50 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM50 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM50 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM50 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM50 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM50 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM50 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86XT4 TRIM50
Gene Names
TRIM50, TRIM50A
Chain
chain:1-487
Reference Genes
BioGPS Gene:135892 TRIM50
COSMIC (genes):TRIM50 TRIM50
CTD Gene:135892 TRIM50
dbSNP Gene:135892 TRIM50
ENSEMBL:ENSG00000146755 TRIM50
HGNC:19017 TRIM50
KEGG:hsa:135892 TRIM50
Monarch:135892 TRIM50
NCBI Gene:135892 TRIM50
OMIM:612548 TRIM50
UCSC:Q86XT4 TRIM50
Reference Transcript
RefSeq:NM_001281450.1 TRIM50
RefSeq:NM_178125.3 TRIM50
RefSeq:NM_001281451.1 TRIM50
Other Identifiers
11732486_a_at
11732487_a_at
11746490_a_at
135892
1556554_PM_at
1556554_at
17058445
231014_PM_at
231014_at
3008998
3009000
3009002
3009004
3009007
3055751
3055753
3055754
3055755
3055759
3055761
3055767
3055768
3055769
3055774
3055775
3055777
3055778
3055779
3055781
3055782
3055784
3056026
8140028
89944_at
A_23_P308136
A_33_P3293748
GO:0003824
GO:0005515
GO:0005737
GO:0005829
GO:0008270
GO:0016567
GO:0016740
GO:0042802
GO:0046872
GO:0061630
GO:0140096
HMNXSV003002069
HMNXSV003033315
Hs.121647.0.A1_3p_at
Hs2.121647.1.A1_3p_at
Hs2.121647.1.A1_3p_x_at
ILMN_1700408
ILMN_1719404
PH_hs_0024639
TC07001496.hg
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
trim50 [cytosol]
(Xenopus tropicalis)
TRIM50 [cytosol]
(Bos taurus)
TRIM50 [cytosol]
(Caenorhabditis elegans)
TRIM50 [cytosol]
(Canis familiaris)
TRIM50 [cytosol]
(Gallus gallus)
TRIM50 [cytosol]
(Mus musculus)
TRIM50 [cytosol]
(Rattus norvegicus)
TRIM50 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001268380.1
,
NP_001268379.1
,
NP_835226.2
ENSEMBL
ENST00000333149
,
ENST00000453152
,
ENSP00000413875
,
ENSP00000327994
OpenTargets
ENSG00000146755
HPA
ENSG00000146755-TRIM50
PRO
Q86XT4
Pharos - Targets
Q86XT4
GlyGen
Q86XT4
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P51668 UBE2D1
3
UBE2D1 [cytosol]
(R-HSA-174236)
UBE2D1 [nucleoplasm]
(R-HSA-174197)
Ub-C85-UBE2D1 [cytosol]
(R-HSA-8864160)
0.556
5
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.556
3
UniProt:O75928-2 PIAS2
1
PIAS2-2 [nucleoplasm]
(R-HSA-2993779)
0.556
3
UniProt:Q6GPH4 XAF1
1
XAF1 [cytosol]
(R-HSA-1015680)
0.556
3
UniProt:O75604 USP2
2
USP2 [cytosol]
(R-HSA-5212661)
USP2 [nucleoplasm]
(R-HSA-5689946)
0.556
3
UniProt:Q969R5 L3MBTL2
2
L3MBTL2 [nucleoplasm]
(R-HSA-6804477)
polySUMO2-K675,K700-L3MBTL2 [nucleoplasm]
(R-HSA-6804480)
0.556
3
UniProt:O60733 PLA2G6
2
PLA2G6 [cytosol]
(R-HSA-201596)
PLA2G6 [mitochondrial inner membrane]
(R-HSA-1524076)
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
0.556
3
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