ADRM1:26S proteaseome binds USP14

Stable Identifier
R-HSA-5689539
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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ADRM1 (Rpn13) interacts with the 26S proteasome base unit PRDM1 (Rpn2) via its amino-terminus and is found in the majority of 26S proteasomes. ADRM1 can bind K48-linked di-Ubiquitin (Schreiner et al. 2008, Husnjak et al. 2008) and several de-ubiquitinating enzymes (DUBs) including PSDM14 (Rpn11, POH1), part of the 26S proteasome, and USP14 (Borodovsky et al. 2001, Reyes-Turcu et al. 2009). These proteasome-associated DUBs disassemble poly-Ub chains and recycle ubiquitin during proteasomal degradation. They may also act to prevent the degradation of mis-tagged proteins.

Literature References
PubMed ID Title Journal Year
11566882 A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14

Borodovsky, A, Kessler, BM, Casagrande, R, Overkleeft, HS, Wilkinson, KD, Ploegh, HL

EMBO J. 2001
Participants
Participant Of
Orthologous Events
Cross References
Target Pathogen
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