Reactome | USP14 [cytosol]

USP14 [cytosol]

Stable Identifier

R-HSA-5689541

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin carboxyl-terminal hydrolase 14 ecNumber3.4.19.12/ecNumber, UBP14_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P54578 USP14

Gene Names

USP14, TGT

Chain

chain:1-494

Reference Genes

BioGPS Gene:9097 USP14

COSMIC (genes):USP14 USP14

CTD Gene:9097 USP14

dbSNP Gene:9097 USP14

ENSEMBL:ENSG00000101557 USP14

HGNC:12612 USP14

KEGG:hsa:9097 USP14

Monarch:9097 USP14

NCBI Gene:9097 USP14

OMIM:607274 USP14

UCSC:P54578 USP14

Reference Transcript

Other Identifiers

11735994_a_at

11735995_a_at

11735996_x_at

11759174_at

16850437

201671_PM_x_at

201671_x_at

201672_PM_s_at

201672_s_at

226567_PM_at

226567_at

36982_at

3775687

3775688

3775689

3775691

3775692

3775693

3775694

3775695

3775697

3775703

3775704

3775705

3775706

3775707

3775708

3775710

3775712

3775714

3775717

3775718

3775719

3775721

3775722

3775723

3775724

3775725

43660_at

44242_at

8019807

9097

A_24_P245330

A_24_P313744

A_33_P3239954

GE59069

GO:0000502

GO:0002376

GO:0003824

GO:0004197

GO:0004843

GO:0004866

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0006508

GO:0007268

GO:0008234

GO:0009986

GO:0016579

GO:0016787

GO:0023052

GO:0030163

GO:0031410

GO:0043161

GO:0043226

GO:0045087

GO:0045202

GO:0050920

GO:0061136

GO:0061578

GO:0070062

GO:0070628

GO:0071108

GO:0098542

GO:0098772

GO:0098978

GO:0099523

GO:0101005

GO:0140096

GO:1904293

GO:2000059

HMNXSV003051254

Hs.1540.1.S1_3p_at

ILMN_1806804

ILMN_2402947

PH_hs_0004387

TC18000003.hg

U30888_at

g4827049_3p_a_at

Participates

as a component of

ADRM1:26S proteasome:USP14 [cytosol] (Homo sapiens)

as an input of

ADRM1:26S proteaseome binds USP14 (Homo sapiens)

This entity regulates

Positively

NLRC5 binds IKBKB and CHUK (Homo sapiens)

Inferred To

Usp14 [cytosol] (Drosophila melanogaster)

Usp14 [cytosol] (Mus musculus)

Usp14 [cytosol] (Rattus norvegicus)

usp14 [cytosol] (Danio rerio)

usp14 [cytosol] (Dictyostelium discoideum)

usp14 [cytosol] (Xenopus tropicalis)

UBP6 [cytosol] (Saccharomyces cerevisiae)

USP14 [cytosol] (Bos taurus)

USP14 [cytosol] (Canis familiaris)

USP14 [cytosol] (Gallus gallus)

USP14 [cytosol] (Plasmodium falciparum)

USP14 [cytosol] (Sus scrofa)

ubp6 [cytosol] (Schizosaccharomyces pombe)

usp-14 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_005142.1, NP_001032411.1

Guide to Pharmacology - Targets

2429

OpenTargets

ENSG00000101557

ENSEMBL

ENST00000400266, ENSP00000261601, ENSG00000101557, ENSP00000383125, ENST00000582707, ENST00000261601, ENSP00000464447

HPA

ENSG00000101557-USP14

GeneCards

USP14

ZINC - Substances

UBP14_HUMAN

ZINC target

P54578

PRO

P54578

Pharos - Targets

P54578

GlyGen

P54578

PDB

7W37, 7W39, 7W3M, 7W3K, 7W3F, 7W3C, 2AYN, 2AYO, 5GJQ, 6LVS, 6IIK, 7W3B, 7W3J, 7W3H, 7W3G, 6IIN, 7W3I, 7W38, 7W3A, 6IIL, 6IIM

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P43686 PSMC4	2	PSMC4 [cytosol] (R-HSA-68777) PSMC4 [nucleoplasm] (R-HSA-174315)	0.527	2
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.527	2
UniProt:O00231 PSMD11	5	PSMD11 [cytosol] (R-HSA-68790) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [secretory granule lumen] (R-HSA-6800943)	0.527	2
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [secretory granule lumen] (R-HSA-6800919)	0.527	2
UniProt:O43242 PSMD3	5	PSMD3 [cytosol] (R-HSA-68798) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [secretory granule lumen] (R-HSA-6800873)	0.527	2
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.527	3
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [secretory granule lumen] (R-HSA-6801036)	0.527	2
UniProt:P35998 PSMC2	5	PSMC2 [cytosol] (R-HSA-68771) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [secretory granule lumen] (R-HSA-6800994)	0.527	2
UniProt:P60896 SEM1	2	SEM1 [cytosol] (R-HSA-8866674) SEM1 [nucleoplasm] (R-HSA-8866665)	0.527	2
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [secretory granule lumen] (R-HSA-6800934)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7
UniProt:Q08209 PPP3CA	2	PPP3CA [cytosol] (R-HSA-201771) PPP3CA [nucleoplasm] (R-HSA-2685599)	0.463	3

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