Reactome | USP14 [cytosol]

USP14 [cytosol]

Stable Identifier

R-HSA-5689541

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin carboxyl-terminal hydrolase 14 ecNumber3.4.19.12/ecNumber, UBP14_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9Y5K5

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External Reference Information

External Reference

UniProt:P54578 USP14

Gene Names

USP14, TGT

Chain

chain:1-494

Reference Genes

BioGPS Gene:9097 USP14

COSMIC (genes):USP14 USP14

CTD Gene:9097 USP14

dbSNP Gene:9097 USP14

ENSEMBL:ENSG00000101557 USP14

ENSEMBL_homo_sapiens_GENE:ENSG00000101557.15 USP14

HGNC:12612 USP14

KEGG Gene (Homo sapiens):9097 USP14

Monarch:9097 USP14

NCBI Gene:9097 USP14

OMIM:607274 USP14

UCSC:P54578 USP14

Reference Transcript

Other Identifiers

11735994_a_at

11735995_a_at

11735996_x_at

11759174_at

16850437

201671_PM_x_at

201671_x_at

201672_PM_s_at

201672_s_at

226567_PM_at

226567_at

36982_at

3775687

3775688

3775692

3775693

3775694

3775695

3775697

3775704

3775705

3775706

3775707

3775708

3775710

3775712

3775714

3775717

3775719

3775721

3775722

3775723

3775724

3775725

43660_at

44242_at

8019807

9097

A_24_P245330

A_24_P313744

A_33_P3239954

GE59069

GO:0000502

GO:0002376

GO:0003824

GO:0004197

GO:0004843

GO:0004866

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005886

GO:0006508

GO:0007268

GO:0008233

GO:0008234

GO:0009986

GO:0016020

GO:0016579

GO:0016787

GO:0023052

GO:0030163

GO:0031410

GO:0036211

GO:0043161

GO:0043226

GO:0045087

GO:0045202

GO:0050920

GO:0061136

GO:0061578

GO:0070062

GO:0070628

GO:0098542

GO:0098772

GO:0140096

GO:1903070

HMNXSV003051254

Hs.1540.1.S1_3p_at

ILMN_1806804

ILMN_2402947

PH_hs_0004387

TC18000003.hg

U30888_at

g4827049_3p_a_at

Participates

as a component of

ADRM1:26S proteasome:USP14 [cytosol] (Homo sapiens)

as an input of

ADRM1:26S proteaseome binds USP14 (Homo sapiens)

This entity regulates

Positively

NLRC5 binds IKBKB and CHUK (Homo sapiens)

Inferred To

zgc:55949 [cytosol] (Danio rerio)

Usp14 [cytosol] (Drosophila melanogaster)

Usp14 [cytosol] (Mus musculus)

Usp14 [cytosol] (Rattus norvegicus)

usp14 [cytosol] (Dictyostelium discoideum)

usp14 [cytosol] (Xenopus tropicalis)

UBP6 [cytosol] (Saccharomyces cerevisiae)

USP14 [cytosol] (Bos taurus)

USP14 [cytosol] (Canis familiaris)

USP14 [cytosol] (Gallus gallus)

USP14 [cytosol] (Plasmodium falciparum)

USP14 [cytosol] (Sus scrofa)

ubp6 [cytosol] (Schizosaccharomyces pombe)

usp-14 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_005142.1, NP_001032411.1

Guide to Pharmacology - Targets

2429

OpenTargets

ENSG00000101557

ZINC - Substances

UBP14_HUMAN

ZINC target

P54578

PRO

P54578

PDB

2AYO, 7W39, 7W3C, 7W3B, 7W3K, 6IIK, 6LVS, 7W3G, 7W38, 6IIL, 7W3M, 7W3H, 6IIM, 6IIN, 7W3A, 5GJQ, 7W3I, 7W3F, 2AYN, 7W3J, 7W37

IntEnz

3.4.19.12

HPA

ENSG00000101557-USP14

GeneCards

P54578

Ensembl

ENST00000261601, ENSP00000383125, ENSP00000261601, ENST00000400266, ENSG00000101557, ENST00000582707, ENSP00000464447

Pharos - Targets

P54578

Orphanet

29701

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62191 PSMC1	2	PSMC1 [nucleoplasm] (R-HSA-174338) PSMC1 [cytosol] (R-HSA-68768)	0.564	2
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.564	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	7
UniProt:Q08209 PPP3CA	2	PPP3CA [nucleoplasm] (R-HSA-2685599) PPP3CA [cytosol] (R-HSA-201771)	0.463	3