UCH proteinases

Stable Identifier
R-HSA-5689603
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser
DUBs of the Ub C-terminal Hydrolase (UCH) family are thiol proteases that have an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions. Humans have four UCH DUBs (UCH-L1, UCH-L3, UCH37/UCH-L5, and BAP1) that can be divided into the smaller UCH DUBs (UCH-L1 and UCH-L3), which cleave small leaving groups from the C-terminus of ubiquitin (Larsen et al. 1998), and the larger UCH DUBs (UCH37 and BAP1), which can disassemble poly-Ub chains (Misaghi et al. 2009, Lam et al. 1997).
Literature References
PubMed ID Title Journal Year
16325574 A genomic and functional inventory of deubiquitinating enzymes

Sixma, TK, Luna-Vargas, MP, Nijman, SM, Velds, A, Brummelkamp, TR, Bernards, R, Dirac, AM

Cell 2005
19243136 Polyubiquitin binding and disassembly by deubiquitinating enzymes

Reyes-Turcu, FE, Wilkinson, KD

Chem. Rev. 2009
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!