UCH proteinases

Stable Identifier
R-HSA-5689603
Type
Pathway
Species
Homo sapiens
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DUBs of the Ub C-terminal Hydrolase (UCH) family are thiol proteases that have an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions. Humans have four UCH DUBs (UCH-L1, UCH-L3, UCH37/UCH-L5, and BAP1) that can be divided into the smaller UCH DUBs (UCH-L1 and UCH-L3), which cleave small leaving groups from the C-terminus of ubiquitin (Larsen et al. 1998), and the larger UCH DUBs (UCH37 and BAP1), which can disassemble poly-Ub chains (Misaghi et al. 2009, Lam et al. 1997).

Literature References
PubMed ID Title Journal Year
19243136 Polyubiquitin binding and disassembly by deubiquitinating enzymes

Reyes-Turcu, FE, Wilkinson, KD

Chem. Rev. 2009
16325574 A genomic and functional inventory of deubiquitinating enzymes

Nijman, SM, Luna-Vargas, MP, Velds, A, Brummelkamp, TR, Dirac, AM, Sixma, TK, Bernards, R

Cell 2005
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