Reactome | ASXL1 [nucleoplasm]

ASXL1 [nucleoplasm]

Stable Identifier

R-HSA-5689645

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Putative Polycomb group protein ASXL1, ASXL1_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - UCH proteinases (Homo sapiens)
      - BAP1 binds BAP1-interacting complex (Homo sapiens)
        
        BAP1-interacting complex [nucleoplasm] (Homo sapiens)
        
        BAP1-interacting core complex [nucleoplasm] (Homo sapiens)
        
        ASXL1,ASXL2 [nucleoplasm] (Homo sapiens)
        
        ASXL1 [nucleoplasm] (Homo sapiens)
        
        BAP1:BAP1-interacting complex [nucleoplasm] (Homo sapiens)
        
        BAP1-interacting complex [nucleoplasm] (Homo sapiens)
        
        BAP1-interacting core complex [nucleoplasm] (Homo sapiens)
        
        ASXL1,ASXL2 [nucleoplasm] (Homo sapiens)
        
        ASXL1 [nucleoplasm] (Homo sapiens)
      - Histone H2A is dubiquitinated by the PR-DUB complex (Homo sapiens)
        
        PR-DUB complex [nucleoplasm] (Homo sapiens)
        
        PR-DUB core complex [nucleoplasm] (Homo sapiens)
        
        ASXL1,ASXL2 [nucleoplasm] (Homo sapiens)
        
        ASXL1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8IXJ9 ASXL1

Gene Names

ASXL1, KIAA0978

Chain

chain:1-1541

Reference Genes

BioGPS Gene:171023 ASXL1

COSMIC (genes):ASXL1 ASXL1

CTD Gene:171023 ASXL1

dbSNP Gene:171023 ASXL1

ENSEMBL:ENSG00000171456.21 ASXL1

HGNC:18318 ASXL1

KEGG Gene (Homo sapiens):171023 ASXL1

Monarch:171023 ASXL1

NCBI Gene:171023 ASXL1

OMIM:612990 ASXL1

UCSC:Q8IXJ9 ASXL1

Reference Transcript

RefSeq:NM_015338.5 ASXL1

Other Identifiers

0001230215

11720165_a_at

11744500_a_at

11744501_a_at

11744933_a_at

11745666_a_at

11747056_a_at

16912552

171023

212234_PM_at

212234_at

212237_PM_at

212237_at

212238_PM_at

212238_at

244519_PM_at

244519_at

34396_at

3881875

3881876

3881877

3881878

3881884

3881886

3881889

3881890

3881892

3881893

3881895

3881898

3881900

3881901

3881902

3881903

3881904

3881905

3881906

3881907

3881908

3881909

3881910

3881911

3881912

3881913

3881914

3881915

3881916

3881917

3881962

3881964

70752_at

8061725

A_14_P109586

A_24_P19337

A_32_P41021

A_33_P3436316

GE53634

GE61702

GO:0000902

GO:0002376

GO:0003007

GO:0003674

GO:0003677

GO:0003682

GO:0003713

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0006325

GO:0006351

GO:0006355

GO:0008134

GO:0008150

GO:0009887

GO:0023052

GO:0030097

GO:0030154

GO:0032526

GO:0032991

GO:0035359

GO:0035517

GO:0035522

GO:0035564

GO:0036211

GO:0042974

GO:0042975

GO:0043167

GO:0043226

GO:0045599

GO:0045944

GO:0046872

GO:0048386

GO:0048534

GO:0048538

GO:0048539

GO:0048856

GO:0048872

GO:0060348

GO:0060430

GO:0072015

HMNXSV003030011

Hs.211193.0.A1_3p_at

Hs.3686.0.A1_3p_at

Hs.3686.0.A2_3p_at

Hs.3686.0.A3_3p_at

ILMN_1726025

PH_hs_0000425

TC20000210.hg

Participates

as a member of

ASXL1,ASXL2 [nucleoplasm] (Homo sapiens)

Inferred To

si:dkey-202m22.4 [nucleoplasm] (Danio rerio)

Asxl1 [nucleoplasm] (Mus musculus)

Asxl1 [nucleoplasm] (Rattus norvegicus)

ASXL1 [nucleoplasm] (Bos taurus)

ASXL1 [nucleoplasm] (Canis familiaris)

ASXL1 [nucleoplasm] (Sus scrofa)

asxl1 [nucleoplasm] (Xenopus tropicalis)

Asx [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_056153.2

OpenTargets

ENSG00000171456

HPA

ENSG00000171456-ASXL1

GeneCards

Q8IXJ9

Ensembl

ENST00000613218, ENSG00000171456, ENST00000620121, ENST00000375687, ENSP00000480487, ENSP00000481978, ENSP00000364839

PRO

Q8IXJ9

Pharos - Targets

Q8IXJ9

Orphanet

20545

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92560 BAP1	1	BAP1 [nucleoplasm] (R-HSA-5689665)	0.793	7
UniProt:Q99PU7	1	Bap1 [nucleoplasm] (R-MMU-5689665)	0.564	3
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.558	6
UniProt:P68306	3	polySUMO3-K50,K146,K443-THRB [nucleoplasm] (R-GGA-4719433) monoSUMO1-K50,K146,K443-THRB [nucleoplasm] (R-GGA-4719421) THRB [nucleoplasm] (R-GGA-446179)	0.527	2
UniProt:P28700 Rxra	5	RXRA [cytosol] (R-MMU-9619757) phospho-p-S21-RXRA [nucleoplasm] (R-MMU-5334811) monoSUMO1-K108-RXRA [nucleoplasm] (R-MMU-4341130) Rxra [nucleoplasm] (R-MMU-442483) RXRA [nucleoplasm] (R-MMU-381319)	0.527	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [cytosol] (R-HSA-9020974) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	2
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.508	2
UniProt:O75530 EED	1	EED [nucleoplasm] (R-HSA-212278)	0.499	5