Reactome | ASXL1 [nucleoplasm]

ASXL1 [nucleoplasm]

Stable Identifier

R-HSA-5689645

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Putative Polycomb group protein ASXL1, ASXL1_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - UCH proteinases (Homo sapiens)
      - BAP1 binds BAP1-interacting complex (Homo sapiens)
        
        BAP1-interacting complex [nucleoplasm] (Homo sapiens)
        
        BAP1-interacting core complex [nucleoplasm] (Homo sapiens)
        
        ASXL1,ASXL2 [nucleoplasm] (Homo sapiens)
        
        ASXL1 [nucleoplasm] (Homo sapiens)
        
        BAP1:BAP1-interacting complex [nucleoplasm] (Homo sapiens)
        
        BAP1-interacting complex [nucleoplasm] (Homo sapiens)
        
        BAP1-interacting core complex [nucleoplasm] (Homo sapiens)
        
        ASXL1,ASXL2 [nucleoplasm] (Homo sapiens)
        
        ASXL1 [nucleoplasm] (Homo sapiens)
      - Histone H2A is dubiquitinated by the PR-DUB complex (Homo sapiens)
        
        PR-DUB complex [nucleoplasm] (Homo sapiens)
        
        PR-DUB core complex [nucleoplasm] (Homo sapiens)
        
        ASXL1,ASXL2 [nucleoplasm] (Homo sapiens)
        
        ASXL1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8IXJ9 ASXL1

Gene Names

ASXL1, KIAA0978

Chain

chain:1-1541

Reference Genes

BioGPS Gene:171023 ASXL1

COSMIC (genes):ASXL1 ASXL1

CTD Gene:171023 ASXL1

dbSNP Gene:171023 ASXL1

ENSEMBL:ENSG00000171456 ASXL1

HGNC:18318 ASXL1

KEGG Gene (Homo sapiens):171023 ASXL1

Monarch:171023 ASXL1

NCBI Gene:171023 ASXL1

OMIM:612990 ASXL1

UCSC:Q8IXJ9 ASXL1

Reference Transcript

RefSeq:NM_015338.5 ASXL1

Other Identifiers

0001230215

11720165_a_at

11744500_a_at

11744501_a_at

11744933_a_at

11745666_a_at

11747056_a_at

16912552

171023

212234_at

212237_at

212238_at

244519_at

34396_at

3881875

3881876

3881877

3881878

3881884

3881886

3881889

3881890

3881892

3881893

3881895

3881898

3881900

3881901

3881902

3881903

3881904

3881905

3881906

3881907

3881908

3881909

3881910

3881911

3881912

3881913

3881914

3881915

3881916

3881917

3881962

3881964

64156

70752_at

8061725

A0A087WWN0

A0A2R8Y4U9

A0A2R8Y5U1

A0A2R8Y627

A0A2R8Y6F0

A0A2R8Y6V0

A0A494C1R1

A_14_P109586

A_24_P19337

A_32_P41021

A_33_P3436316

AAH33284

AAI37279

AAI37281

AB023195

AJ438952

AL034550

AL117518

AL117647

AL121583

ASXL1

ASXL1-202

ASXL1-210

ASXL1-212

BAA76822

BC033284

BC137278

BC137280

CAB55975

CAB56029

CAD27708

CCDS13201

ENSG00000171456

ENSP00000364839

ENSP00000480487

ENSP00000481978

ENST00000375687

ENST00000375687.9

ENST00000613218

ENST00000613218.4

ENST00000620121

ENST00000620121.4

EntrezGene:171023

EntrezGene:ASXL1

GE53634

GE61702

GO:0000228

GO:0000790

GO:0000902

GO:0002376

GO:0003007

GO:0003674

GO:0003677

GO:0003682

GO:0003713

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006351

GO:0006355

GO:0006464

GO:0007165

GO:0008134

GO:0008150

GO:0009058

GO:0009887

GO:0016579

GO:0030097

GO:0030154

GO:0032526

GO:0032991

GO:0034641

GO:0035359

GO:0035517

GO:0035522

GO:0042592

GO:0042974

GO:0042975

GO:0043167

GO:0043226

GO:0045599

GO:0045944

GO:0046872

GO:0048386

GO:0048534

GO:0048538

GO:0048539

GO:0048856

GO:0048872

GO:0051276

GO:0060348

GO:0060430

H0YJC9

HGNC:18318

HPA064156

Hs.211193.0.A1_3p_at

Hs.3686.0.A1_3p_at

Hs.3686.0.A2_3p_at

Hs.3686.0.A3_3p_at

ILMN_1726025

IPR007759

IPR024811

IPR024815

IPR026905

IPR028020

KF495689

LRG_630

LRG_630t1

MIM:605039

MIM:612990

MIM:614286

NM_015338

NP_056153

PF05066

PF13919

PF13922

PH_hs_0000425

Q498B9

Q5JWS8

Q6P1M8

Q76L82

TC20000210.hg

UPI000018691A

XM_006723727

XM_006723730

XM_011528652

XM_017027704

XM_017027705

XM_017027706

XP_006723790

XP_006723793

XP_011526954

XP_016883193

XP_016883194

XP_016883195

Participant Of

hasMember

ASXL1,ASXL2 [nucleoplasm]

Inferred To

ASXL1 [nucleoplasm] (Bos taurus)

ASXL1 [nucleoplasm] (Canis familiaris)

ASXL1 [nucleoplasm] (Danio rerio)

ASXL1 [nucleoplasm] (Drosophila melanogaster)

ASXL1 [nucleoplasm] (Mus musculus)

ASXL1 [nucleoplasm] (Rattus norvegicus)

ASXL1 [nucleoplasm] (Sus scrofa)

ASXL1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_056153.2

OpenTargets

ENSG00000171456

GeneCards

Q8IXJ9

PRO

Q8IXJ9

Orphanet

20545

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92560 BAP1	1	BAP1 [nucleoplasm] (R-HSA-5689665)	0.793	7
UniProt:Q99PU7	1	BAP1 [nucleoplasm] (R-MMU-5689665)	0.564	3
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.558	6
UniProt:P68306	3	SUMO1-K50,K146,K443-THRB [nucleoplasm] (R-GGA-4719421) SUMO3-K50,K146,K443-THRB [nucleoplasm] (R-GGA-4719433) THRB [nucleoplasm] (R-GGA-446179)	0.527	2
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	2
UniProt:P28700 Rxra	5	phospho-p-S21-RXRA [nucleoplasm] (R-MMU-5334811) RXRA [cytosol] (R-MMU-9619757) SUMO1-K108-RXRA [nucleoplasm] (R-MMU-4341130) Rxra [nucleoplasm] (R-MMU-442483) RXRA [nucleoplasm] (R-MMU-381319)	0.527	2
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356)	0.508	2
UniProt:O75530 EED	1	EED [nucleoplasm] (R-HSA-212278)	0.499	5