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Factor V precursor [COPII-coated ER to Golgi transport vesicle]
Stable Identifier
R-HSA-5689792
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
COPII-coated ER to Golgi transport vesicle
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
CSNK1D phosphorylates SEC23 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Nucleotide exchange on RAB1 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
CSNK1D phosphorylates SEC23 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Nucleotide exchange on RAB1 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
External Reference Information
External Reference
UniProt:P12259 F5
Gene Names
F5
Chain
signal peptide:1-28, chain:29-2224, chain:29-737, propeptide:738-1573, chain:1574-2224
Reference Genes
BioGPS Gene:2153 F5
COSMIC (genes):F5 F5
CTD Gene:2153 F5
dbSNP Gene:2153 F5
ENSEMBL:ENSG00000198734 F5
HGNC:3542 F5
KEGG Gene (Homo sapiens):2153 F5
Monarch:2153 F5
NCBI Gene:2153 F5
OMIM:612309 F5
UCSC:P12259 F5
Reference Transcript
RefSeq:NM_000130.4 F5
Other Identifiers
0006200270
11723553_at
11723554_at
11751042_a_at
11758395_s_at
16696187
204713_s_at
204714_s_at
2153
231029_at
2443369
2443371
2443372
2443373
2443374
2443375
2443377
2443378
2443381
2443382
2443383
2443384
2443385
2443386
2443388
2443389
2443391
2443392
2443393
2443394
2443395
2443396
2443397
2443398
2443399
2443400
2443402
2443403
2443404
2443405
2443406
2443407
2443408
2443410
2443412
2443413
2443414
2443415
35245_at
62710_at
7922174
A_23_P148768
A_32_P41604
GE57848
GO:0002576
GO:0003013
GO:0003674
GO:0005507
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005783
GO:0005788
GO:0005886
GO:0006464
GO:0006810
GO:0006888
GO:0006950
GO:0007596
GO:0007599
GO:0008015
GO:0008150
GO:0016020
GO:0016192
GO:0022607
GO:0030134
GO:0031091
GO:0031093
GO:0031410
GO:0033116
GO:0043167
GO:0043226
GO:0043687
GO:0044267
GO:0046872
GO:0048208
GO:0061024
GO:0065003
GO:1903561
HMNXSV003023557
Hs.165077.0.A1_3p_at
Hs.30054.0.S1_3p_a_at
ILMN_1709233
M16967_at
PH_hs_0002589
PH_hs_0020466
TC01003498.hg
g10518500_3p_a_at
Participates
as a member of
glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
Other forms of this molecule
factor V [platelet alpha granule lumen]
F5(535-737) [extracellular region]
F5(335-534) [extracellular region]
F5(29-334) [extracellular region]
F5(29-534) [extracellular region]
factor V activation peptide [extracellular region]
Factor V precursor [endoplasmic reticulum lumen]
p-Factor V precursor [endoplasmic reticulum lumen]
Factor V precursor [endoplasmic reticulum-Golgi intermediate compartment membrane]
factor Va light chain [plasma membrane]
factor Va heavy chain [plasma membrane]
factor Va light chain [extracellular region]
factor Va heavy chain [extracellular region]
factor V [extracellular region]
Inferred To
F5 [COPII-coated ER to Golgi transport vesicle]
(Canis familiaris)
F5 [COPII-coated ER to Golgi transport vesicle]
(Gallus gallus)
F5 [COPII-coated ER to Golgi transport vesicle]
(Mus musculus)
F5 [COPII-coated ER to Golgi transport vesicle]
(Sus scrofa)
f5 [COPII-coated ER to Golgi transport vesicle]
(Danio rerio)
Cross References
RefSeq
NP_000121.2
Guide to Pharmacology - Targets
2606
OpenTargets
ENSG00000198734
ZINC - Substances
FA5_HUMAN
ZINC target
P12259
PRO
P12259
GlyGen
P12259
PDB
3P6Z
,
3S9C
,
1CZV
,
7KVE
,
3P70
,
7KVF
,
1CZT
,
7KXY
,
1CZS
GeneCards
P12259
HPA
ENSG00000198734-F5
Ensembl
ENSG00000198734
,
ENSP00000356771
,
ENST00000367797
Pharos - Targets
P12259
ZINC - Predictions - Purchasable
FA5_HUMAN
Orphanet
16014
HMDB Protein
HMDBP02118
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