Reactome | Factor V precursor [COPII-coated ER to Golgi transport vesicle]

Factor V precursor [COPII-coated ER to Golgi transport vesicle]

Stable Identifier

R-HSA-5689792

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

COPII-coated ER to Golgi transport vesicle

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
      - COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
      - CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
      - Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
      - Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)

External Reference Information

External Reference

UniProt:P12259 F5

Gene Names

Chain

signal peptide:1-28, chain:29-2224, chain:29-737, propeptide:738-1573, chain:1574-2224

Reference Genes

BioGPS Gene:2153 F5

COSMIC (genes):F5 F5

CTD Gene:2153 F5

dbSNP Gene:2153 F5

ENSEMBL:ENSG00000198734 F5

ENSEMBL_homo_sapiens_GENE:ENSG00000198734 F5

HGNC:3542 F5

KEGG Gene (Homo sapiens):2153 F5

Monarch:2153 F5

NCBI Gene:2153 F5

OMIM:612309 F5

UCSC:P12259 F5

Reference Transcript

RefSeq:NM_000130.4 F5

Other Identifiers

0006200270

11723553_at

11723554_at

11751042_a_at

16696187

1CZS

1CZT

1CZV

1FV4

1Y61

2036

204713_s_at

204714_s_at

2153

2443373

2443374

2443375

2443377

2443378

2443381

2443382

2443383

2443384

2443385

2443386

2443388

2443389

2443391

2443392

2443393

2443394

2443395

2443396

2443397

2443398

2443399

2443400

2443402

2443403

2443404

2443405

2443406

2443407

2443408

2443410

2443412

2443413

2443414

2443415

35245_at

3P6Z

3P70

3S9C

7922174

A0A0A0MRJ7

A_23_P148768

AAA52424

AAB59401

AAB59532

AAQ55063

ABD23003

AJ297255

AK291613

AY364535

BAF84302

CAC82573

CCDS1281

DQ377944

ENSG00000198734

ENSP00000356771

ENST00000367797

ENST00000367797.7

EntrezGene:2153

F5-202

g10518500_3p_a_at

GE57848

GO:0000139

GO:0002576

GO:0003013

GO:0003674

GO:0005507

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005788

GO:0005886

GO:0006464

GO:0006810

GO:0006888

GO:0007596

GO:0007599

GO:0008015

GO:0016020

GO:0016192

GO:0022607

GO:0030134

GO:0031091

GO:0031093

GO:0031410

GO:0033116

GO:0043167

GO:0043226

GO:0043687

GO:0044267

GO:0046872

GO:0048208

GO:0061024

GO:0065003

GO:1903561

HGNC:3542

HPA002036

Hs.30054.0.S1_3p_a_at

ILMN_1709233

IPR000421

IPR008972

IPR008979

IPR011707

IPR024715

IPR033138

L32755

L32756

L32757

L32758

L32759

L32760

L32761

L32762

L32763

L32764

L32765

L32766

L32767

L32768

L32769

L32770

L32771

L32772

L32773

L32774

L32775

L32776

L32777

L32778

L32779

LRG_553

M14335

M16967

M16967_at

MIM:188055

MIM:227400

MIM:600880

MIM:601367

MIM:612309

MIM:614389

NM_000130

NP_000121

PF00754

PF07732

PH_hs_0002589

SM00231

TC01003498.hg

UPI000016A8CE

XM_017000660

XP_016856149

Z99572

Participant Of

hasMember

glycosylated FV, FVIII precursor [COPII-coated ER to Golgi transport vesicle]

Other forms of this molecule

F5(535-737) [extracellular region]

F5(335-534) [extracellular region]

F5(29-334) [extracellular region]

F5(29-534) [extracellular region]

factor V [platelet alpha granule lumen]

p-Factor V precursor [endoplasmic reticulum lumen]

Factor V precursor [endoplasmic reticulum-Golgi intermediate compartment membrane]

Factor V precursor [endoplasmic reticulum lumen]

factor V activation peptide [extracellular region]

factor V [extracellular region]

factor Va heavy chain [extracellular region]

factor Va light chain [extracellular region]

factor Va heavy chain [plasma membrane]

factor Va light chain [plasma membrane]

Inferred To

Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Bos taurus)

Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Canis familiaris)

Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Danio rerio)

Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Gallus gallus)

Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Mus musculus)

Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Sus scrofa)

Factor V precursor [COPII-coated ER to Golgi transport vesicle] (Xenopus tropicalis)

Cross References

RefSeq

NP_000121.2

OpenTargets

ENSG00000198734

ZINC - Substances

FA5_HUMAN

GeneCards

P12259

ZINC target

P12259

PRO

P12259

ZINC - Predictions - Purchasable

FA5_HUMAN

Orphanet

16014

HMDB Protein

HMDBP02118

PDB

3P70, 3P6Z, 1CZT, 1FV4, 1CZS, 1CZV, 3S9C, 1Y61