Recruitment of XPA and release of CAK

Stable Identifier
R-HSA-5689861
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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XPA binds the DNA damage site through interaction with the TFIIH complex subunit GTF2H5 (TTDA) (Ziani et al. 2014), and also interacts with the DDB2 subunit of the UV-DDB complex (Wakasugi et al. 2001, Wakasugi et al. 2009, Takedachi et al. 2010). PARylated PARP1 (or possibly PARP2) (King et al. 2012) facilitates XPA association with chromatin. Binding of XPA is accompanied by the release of the CAK subcomplex from the TFIIH complex (Coin et al. 2008).

Literature References
PubMed ID Title Journal Year
11278856 Damaged DNA-binding protein DDB stimulates the excision of cyclobutane pyrimidine dimers in vitro in concert with XPA and replication protein A

Wakasugi, M, Shimizu, M, Morioka, H, Linn, S, Nikaido, O, Matsunaga, T

J. Biol. Chem. 2001
23038248 Poly(ADP-ribose) contributes to an association between poly(ADP-ribose) polymerase-1 and xeroderma pigmentosum complementation group A in nucleotide excision repair

King, BS, Cooper, KL, Liu, KJ, Hudson, LG

J. Biol. Chem. 2012
19056823 Physical and functional interaction between DDB and XPA in nucleotide excision repair

Wakasugi, M, Kasashima, H, Fukase, Y, Imura, M, Imai, R, Yamada, S, Cleaver, JE, Matsunaga, T

Nucleic Acids Res. 2009
20368362 DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA

Takedachi, A, Saijo, M, Tanaka, K

Mol. Cell. Biol. 2010
25154395 Sequential and ordered assembly of a large DNA repair complex on undamaged chromatin

Ziani, S, Nagy, Z, Alekseev, S, Soutoglou, E, Egly, JM, Coin, F

J. Cell Biol. 2014
18614043 Nucleotide excision repair driven by the dissociation of CAK from TFIIH

Coin, F, Oksenych, V, Mocquet, V, Groh, S, Blattner, C, Egly, JM

Mol. Cell 2008
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