Reactome: A Curated Pathway Database

Josephin domain DUBs

Stable Identifier
R-HSA-5689877
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The Josephin domain is present in four human DUBs: Ataxin-3 (ATXN3), ATXN3L, Josephin-1 (JOSD1) and JOSD2. All have been shown to possess DUB activity (Tzveltkov & Breuer 2007, Weeks et al. 2011). Josephin domain DUBs may specialize in distinguishing between polyubiquitin chains of different lengths (Eletr & Wilkinson 2014).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
hasEvent
Orthologous Events
Cross References
BioModels Database