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Josephin domain DUBs

Stable Identifier
R-HSA-5689877
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The Josephin domain is present in four human DUBs: Ataxin-3 (ATXN3), ATXN3L, Josephin-1 (JOSD1) and JOSD2. All have been shown to possess DUB activity (Tzveltkov & Breuer 2007, Weeks et al. 2011). Josephin domain DUBs may specialize in distinguishing between polyubiquitin chains of different lengths (Eletr & Wilkinson 2014).

Literature References
PubMed ID Title Journal Year
23845989 Regulation of proteolysis by human deubiquitinating enzymes Biochim. Biophys. Acta 2014
Participants
Participant Of
hasEvent
Orthologous Events
Cross References
BioModels Database