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Ub-specific processing proteases

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

Ub-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved motifs with N- or C-terminal extensions and insertions occurring between the conserved motifs (Ye et al. 2009). Two highly conserved regions comprise the catalytic triad, the Cys-box (Cys) and His-box (His and Asp/Asn) (Nijman et al. 2005, Ye et al. 2009, Reyes-Turcu & Wilkinson 2009). They recognize their substrates by interactions of the variable regions with the substrate protein directly, or via scaffolds or adapters in multiprotein complexes.

Literature References
PubMed ID Title Journal Year
16325574 A genomic and functional inventory of deubiquitinating enzymes Cell 2005
Participant Of
Orthologous Events
Cross References
BioModels Database