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USP2 [nucleoplasm]
Stable Identifier
R-HSA-5689946
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Degradation (Homo sapiens)
USP2 binds the heterodimer of MDM2 and MDM4 (Homo sapiens)
USP2 [nucleoplasm] (Homo sapiens)
USP2:PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Homo sapiens)
USP2 [nucleoplasm] (Homo sapiens)
USP2 deubiquitinates MDM2,MDM4 (Homo sapiens)
USP2 [nucleoplasm] (Homo sapiens)
USP2:PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Homo sapiens)
USP2 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP2 deubiquitinates MDM2,MDM4 (Homo sapiens)
USP2 [nucleoplasm] (Homo sapiens)
USP2:PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Homo sapiens)
USP2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75604 USP2
Gene Names
USP2, UBP41
Chain
chain:1-605
Reference Genes
BioGPS Gene:9099 USP2
COSMIC (genes):USP2 USP2
CTD Gene:9099 USP2
dbSNP Gene:9099 USP2
ENSEMBL:ENSG00000036672 USP2
HGNC:12618 USP2
KEGG Gene (Homo sapiens):9099 USP2
Monarch:9099 USP2
NCBI Gene:9099 USP2
OMIM:604725 USP2
UCSC:O75604 USP2
Reference Transcript
RefSeq:XM_005271722.2 USP2
RefSeq:NM_001243759.1 USP2
RefSeq:XM_005271721.4 USP2
RefSeq:NM_171997.2 USP2
RefSeq:NM_004205.4 USP2
Other Identifiers
0003440156
0003440341
0005270184
11724044_a_at
11724045_a_at
11740198_a_at
16745343
207213_s_at
229337_at
230965_at
3394355
3394357
3394358
3394360
3394361
3394362
3394365
3394367
3394368
3394370
3394371
3394373
3394374
3394375
3394378
3394379
3394387
3394388
3394397
3394398
3394399
34901_at
56580_at
7952249
90053_at
9099
A_23_P24966
A_24_P107317
GE54715
GE56913
GO:0000122
GO:0000278
GO:0003674
GO:0004197
GO:0004843
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005856
GO:0006464
GO:0006508
GO:0006511
GO:0007049
GO:0007517
GO:0008150
GO:0008233
GO:0008234
GO:0009056
GO:0009058
GO:0016020
GO:0016579
GO:0016787
GO:0019899
GO:0030332
GO:0031625
GO:0032922
GO:0034641
GO:0036459
GO:0042802
GO:0043153
GO:0043167
GO:0043226
GO:0045475
GO:0045931
GO:0046872
GO:0048471
GO:0048511
GO:0048512
GO:0048856
GO:0050821
Hs.125877.0.A1_3p_at
Hs.125877.0.A1_3p_x_at
Hs.23690.0.A1_3p_at
ILMN_1653940
ILMN_1705627
ILMN_1755502
PH_hs_0007134
TC11002370.hg
g4759291_3p_a_at
Participant Of
input
USP2 binds the heterodimer of MDM2 and MDM4
output
USP2 deubiquitinates MDM2,MDM4
hasComponent
USP2:PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm]
Other forms of this molecule
USP2 [cytosol]
Inferred To
Usp2 [nucleoplasm] (Drosophila melanogaster)
Homologues of USP2 [nucleoplasm] (Dictyostelium discoideum)
Homologues of USP2 [nucleoplasm] (Plasmodium falciparum)
cyk-3 [nucleoplasm] (Caenorhabditis elegans)
usp2a [nucleoplasm] (Danio rerio)
USP2 [nucleoplasm] (Canis familiaris)
USP2 [nucleoplasm] (Dictyostelium discoideum)
USP2 [nucleoplasm] (Gallus gallus)
USP2 [nucleoplasm] (Plasmodium falciparum)
USP2 [nucleoplasm] (Sus scrofa)
USP2 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_741994.1
,
XP_005271779.1
,
NP_001230688.1
,
XP_005271778.1
,
NP_004196.4
OpenTargets
ENSG00000036672
IntEnz
3.4.19.12
GeneCards
O75604
HPA
ENSG00000036672-USP2
Ensembl
ENST00000525735
,
ENSP00000436952
,
ENST00000455332
,
ENSG00000036672
,
ENST00000260187
,
ENSP00000407842
,
ENSP00000260187
ZINC target
O75604
PRO
O75604
HMDB Protein
HMDBP11576
PDB
3V6E
,
5XU8
,
2HD5
,
3NHE
,
2IBI
,
3V6C
,
6DGF
,
5XVE
Interactors (106)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12933 TRAF2
5
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.781
7
UniProt:Q9GZM8 NDEL1
1
NDEL1 [cytosol]
(R-HSA-376258)
0.718
6
UniProt:Q9NSC5 HOMER3
1
HOMER3 [cytosol]
(R-HSA-6794236)
0.718
6
UniProt:Q8N1B4 VPS52
1
VPS52 [trans-Golgi network membrane]
(R-HSA-6811029)
0.718
6
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.718
6
UniProt:Q9BRK4 LZTS2
0.718
6
UniProt:Q08379 GOLGA2
3
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.718
6
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.718
6
UniProt:P19012 KRT15
1
KRT15 [cytosol]
(R-HSA-6809589)
0.703
5
UniProt:Q969G2 LHX4
1
LHX4 [nucleoplasm]
(R-HSA-9010585)
0.666
4
UniProt:Q9H596 DUS21
0.556
3
UniProt:Q9BSW2 CRACR2A
2
CRACR2A [specific granule lumen]
(R-HSA-6799553)
CRACR2A [extracellular region]
(R-HSA-6806289)
0.556
3
UniProt:Q92764 KRT35
1
KRT35 [cytosol]
(R-HSA-6809595)
0.556
3
UniProt:Q8NHQ1 CEP70
1
CEP70 [cytosol]
(R-HSA-380257)
0.556
3
IntAct:EBI-23194311 CCSB ORF ID
0.556
3
UniProt:P35609 ACTN2
3
ACTN2 [platelet alpha granule lumen]
(R-HSA-349727)
ACTN2 [cytosol]
(R-HSA-390562)
ACTN2 [extracellular region]
(R-HSA-349725)
0.556
3
UniProt:Q8IYA8 IHO1
0.556
3
UniProt:Q5TA45 INTS11
1
CPSF3L [nucleoplasm]
(R-HSA-6807411)
0.556
3
UniProt:O75564-2 O755642
0.556
3
UniProt:Q9UBR4-2 LHX3
0.556
3
UniProt:Q8ND90 PNMA1
0.556
3
UniProt:Q13137 CACO2
0.556
3
UniProt:Q7Z3Y8 KRT27
1
KRT27 [cytosol]
(R-HSA-6809587)
0.556
3
UniProt:Q5JR59-3 MTUS2
0.556
3
UniProt:O60504 SORBS3
1
SORBS3 [cytosol]
(R-HSA-445805)
0.556
3
UniProt:Q58EX7 PKHG4
0.556
3
UniProt:Q14451-3 GRB7
0.556
3
UniProt:P56945 BCAR1
4
p-Y12-BCAR1 [cytosol]
(R-HSA-5218739)
p-Y-BCAR1 [cytosol]
(R-HSA-372645)
p-Y165,Y664-BCAR1 [cytosol]
(R-HSA-8848723)
BCAR1 [cytosol]
(R-HSA-201625)
0.556
3
UniProt:Q9GZV8 PRDM14
1
PRDM14 [nucleoplasm]
(R-HSA-1112608)
0.556
3
UniProt:Q08117-2 TLE5
0.556
5
UniProt:Q9UK41-2 VPS28
0.556
3
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:Q9NRA8 4ET
0.556
3
UniProt:Q13084 MRPL28
1
MRPL28 [mitochondrial inner membrane]
(R-HSA-5368246)
0.556
3
UniProt:Q8N9I9 DTX3
0.556
3
UniProt:A6NC98 CC88B
0.556
3
UniProt:Q9Y4K3 TRAF6
8
TRAF6 [cytosol]
(R-HSA-166366)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
0.556
3
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.556
3
UniProt:A2RRN7 A2RRN7
0.556
3
UniProt:Q8WWB3 DYDC1
0.556
3
UniProt:Q15654 TRIP6
0.556
3
UniProt:Q6MZQ0 PRR5L
0.556
3
UniProt:Q13077 TRAF1
3
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:Q9UKT9 IKZF3
0.556
3
UniProt:P60903 S100A10
1
S100A10 [external side of plasma membrane]
(R-HSA-5336168)
0.556
3
UniProt:Q96CA5 BIRC7
0.556
3
UniProt:Q8WW24 TEKT4
0.556
3
UniProt:O76011 KRT34
1
KRT34 [cytosol]
(R-HSA-6809608)
0.556
3
UniProt:Q96JN2-2 CCDC136
0.556
3
UniProt:Q15276 RABEP1
1
RABEP1 [early endosome membrane]
(R-HSA-2029004)
0.556
3
UniProt:I6L9F6 I6L9F6
0.556
3
UniProt:P36406 TRI23
0.556
3
UniProt:Q9UJC3 HOOK1
0.556
3
UniProt:Q8WTU0 DDI1
0.556
3
IntAct:EBI-16435328 CCSB ORF ID
0.556
3
UniProt:Q5JR59 MTUS2
0.556
3
UniProt:O96006 ZBED1
1
ZBED1 [nucleoplasm]
(R-HSA-8956376)
0.556
3
UniProt:Q03169 TNAP2
0.556
3
UniProt:Q86V38 Q86V38
0.556
3
UniProt:A6NEM1 GG6L9
0.556
3
UniProt:Q674X7-2 KAZN
0.556
3
UniProt:Q2TAC2 CCD57
0.556
3
UniProt:Q86U10 ASPG
1
ASPG [cytosol]
(R-HSA-6797634)
0.556
3
UniProt:O43482 OIP5
1
OIP5 [nucleoplasm]
(R-HSA-606286)
0.556
3
UniProt:Q9NYB9-2 ABI2
0.556
3
UniProt:Q16633 OBF1
0.556
3
UniProt:Q99932-2 SPAG8
0.556
3
UniProt:P57678 GEMIN4
2
GEMIN4 [cytosol]
(R-HSA-191836)
GEMIN4 [nucleoplasm]
(R-HSA-191841)
0.556
3
UniProt:Q6PI77 BHLH9
0.556
3
UniProt:Q9UJV3-2 MID2
0.556
3
UniProt:O75140-2 DEPDC5
0.556
3
UniProt:Q70EL1-9 USP54
0.556
3
UniProt:Q96MT8-3 CEP63
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
PICK1 [plasma membrane]
(R-HSA-416989)
0.556
3
UniProt:Q9H257-2 CARD9
0.556
3
UniProt:Q4G0R1 Q4G0R1
0.556
3
UniProt:Q9NZV7 ZIM2
1
ZIM2 [nucleoplasm]
(R-HSA-974996)
0.556
3
UniProt:Q59EK9-3 RUNDC3A
0.556
3
UniProt:Q9NRI5-2 DISC1
0.556
3
UniProt:Q96ED9-2 HOOK2
0.556
3
UniProt:Q08043 ACTN3
1
ACTN3 [cytosol]
(R-HSA-390565)
0.556
3
UniProt:P51692 STAT5B
5
p-STAT5B [cytosol]
(R-HSA-8983127)
p-STAT5B [nucleoplasm]
(R-HSA-8982834)
p-Y699-STAT5B [nucleoplasm]
(R-HSA-508016)
p-Y699-STAT5B [cytosol]
(R-HSA-507939)
STAT5B [cytosol]
(R-HSA-380737)
0.556
3
UniProt:Q4V328 GRAP1
0.556
3
UniProt:P07196 NEFL
1
NEFL [cytosol]
(R-HSA-432284)
0.556
3
UniProt:Q96N16 JKIP1
0.556
3
UniProt:Q5VZ52 MORN5
0.556
3
UniProt:A6NLX3 SPDE4
0.556
3
UniProt:Q96B26 EXOSC8
2
EXOSC8 [cytosol]
(R-HSA-429912)
EXOSC8 [nucleoplasm]
(R-HSA-6791571)
0.556
3
UniProt:Q14525 KRT33B
1
KRT33B [cytosol]
(R-HSA-6809594)
0.556
3
UniProt:Q8HWS3 RFX6
1
RFX6 [nucleoplasm]
(R-HSA-8931801)
0.556
3
UniProt:Q8N6Y0 USBP1
0.556
3
UniProt:Q9BVG8 KIFC3
0.556
3
UniProt:Q8N4Y2-3 CRACR2B
0.556
3
UniProt:P12814 ACTN1
3
ACTN1 [platelet alpha granule lumen]
(R-HSA-349724)
ACTN1 [cytosol]
(R-HSA-354096)
ACTN1 [extracellular region]
(R-HSA-349722)
0.556
3
UniProt:O14492-2 O144922
0.556
3
UniProt:Q5JST6 EFHC2
0.556
3
UniProt:Q9NYA3 GOG6A
0.556
3
UniProt:Q03252 LMNB2
0.556
3
UniProt:Q8TD16-2 BICD2
0.556
3
UniProt:Q86XT4 TRIM50
1
TRIM50 [cytosol]
(R-HSA-5688976)
0.556
3
UniProt:Q86VP1 TAX1BP1
1
TAX1BP1 [cytosol]
(R-HSA-937346)
0.556
3
UniProt:Q9BVG8-5 KIFC3
0.556
3
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.556
3
UniProt:Q96CV9 OPTN
4
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
0.556
3
UniProt:O00471 EXOC5
2
EXOC5 [cytosol]
(R-HSA-5623383)
EXOC5 [cytosol]
(R-HSA-265045)
0.556
3
UniProt:Q15742 NAB2
1
NAB2 [nucleoplasm]
(R-HSA-9612177)
0.556
3
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