Reactome | USP2 [nucleoplasm]

USP2

Stable Identifier

R-HSA-5689946

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O75604 USP2

Gene Names

USP2, UBP41

Chain

chain:1-605

Reference Genes

BioGPS Gene:9099 USP2

COSMIC (genes):USP2 USP2

CTD Gene:9099 USP2

dbSNP Gene:9099 USP2

ENSEMBL:ENSG00000036672 USP2

HGNC:12618 USP2

KEGG Gene (Homo sapiens):hsa:9099 USP2

Monarch:9099 USP2

NCBI Gene:9099 USP2

OMIM:604725 USP2

UCSC:O75604 USP2

Reference Transcript

Other Identifiers

0003440156

0003440341

0005270184

11724044_a_at

11724045_a_at

11740198_a_at

16745343

207213_s_at

229337_at

230965_at

2HD5

2IBI

3394357

3394358

3394360

3394361

3394362

3394365

3394367

3394368

3394370

3394371

3394373

3394374

3394375

3394378

3394379

3394387

3394388

3394397

3394398

3394399

34901_at

3NHE

3V6C

3V6E

56580_at

6777

7222

7952249

90053_at

9099

A_23_P24966

A_24_P107317

AAC28392

AAH02854

AAH02955

AAH41366

AAN65363

ACA06096

ACA06097

AF079564

AF440755

AK057225

AK292255

AP003396

BAB71388

BAF84944

BC002854

BC002955

BC041366

CCDS58189

CCDS8422

CCDS8423

CH471065

EAW67484

EAW67485

EAW67486

EF445044

ENSG00000036672

ENSP00000260187

ENSP00000407842

ENSP00000436952

ENST00000260187

ENST00000455332

ENST00000525735

EntrezGene:9099

g4759291_3p_a_at

GE54715

GE56913

GO:0000122

GO:0000278

GO:0003674

GO:0004197

GO:0004843

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005856

GO:0005938

GO:0006464

GO:0006508

GO:0006511

GO:0007049

GO:0007517

GO:0008150

GO:0008233

GO:0008234

GO:0009056

GO:0009058

GO:0016020

GO:0016579

GO:0016787

GO:0019899

GO:0030332

GO:0031625

GO:0032922

GO:0034641

GO:0036459

GO:0042802

GO:0043153

GO:0043167

GO:0043226

GO:0045475

GO:0045931

GO:0046872

GO:0048471

GO:0048511

GO:0048512

GO:0048856

GO:0050821

HGNC:12618

HPA006777

HPA007222

Hs.125877.0.A1_3p_at

Hs.125877.0.A1_3p_x_at

Hs.23690.0.A1_3p_at

ILMN_1653940

ILMN_1705627

ILMN_1755502

IPR001394

IPR018200

IPR028889

MIM:604725

NM_001243759

NM_004205

NM_171997

NP_001230688

NP_004196

NP_741994

PF00443

PH_hs_0007134

TC11002370.hg

uc001pwl.5

uc001pwm.5

uc001pwn.5

UPI0000074749

UPI00001379D8

UPI000049DD57

USP2

USP2-201

USP2-202

USP2-204

XM_005271721

XM_005271722

XM_017018539

XP_005271778

XP_005271779

XP_016874028

Participant Of

input

USP2 binds the heterodimer of MDM2 and MDM4

output

USP2 deubiquitinates MDM2,MDM4

hasComponent

USP2:PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm]

Other forms of this molecule

USP2 [cytosol]

Inferred To

Homologues of USP2 [nucleoplasm] (Danio rerio)

Homologues of USP2 [nucleoplasm] (Drosophila melanogaster)

Homologues of USP2 [nucleoplasm] (Gallus gallus)

Homologues of USP2 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of USP2 [nucleoplasm] (Sus scrofa)

Homologues of USP2 [nucleoplasm] (Xenopus tropicalis)

USP2 [nucleoplasm] (Bos taurus)

USP2 [nucleoplasm] (Canis familiaris)

USP2 [nucleoplasm] (Danio rerio)

USP2 [nucleoplasm] (Drosophila melanogaster)

USP2 [nucleoplasm] (Gallus gallus)

USP2 [nucleoplasm] (Mus musculus)

USP2 [nucleoplasm] (Rattus norvegicus)

USP2 [nucleoplasm] (Saccharomyces cerevisiae)

USP2 [nucleoplasm] (Sus scrofa)

USP2 [nucleoplasm] (Taeniopygia guttata)

USP2 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001230688.1, XP_005271778.1, NP_004196.4, XP_005271779.1, NP_741994.1

GeneCards

O75604

DOCK Blaster

3V6E, 2HD5, 2IBI, 3V6C, 3NHE

ZINC target

O75604

PRO

O75604

BRENDA (Homo sapiens)

3.4.19.12

HMDB Protein

HMDBP11576

PDB

3V6E, 5XU8, 2HD5, 5XVE, 3NHE, 2IBI, 3V6C

Interactors (107)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.764	6
UniProt:P19012 KRT15	1	KRT15 [cytosol] (R-HSA-6809589)	0.703	5
UniProt:Q9GZM8 NDEL1	1	NDEL1 [cytosol] (R-HSA-376258)	0.696	5
UniProt:Q9NSC5 HOMER3	1	HOMER3 [cytosol] (R-HSA-6794236)	0.696	5
UniProt:Q8N1B4 VPS52	1	VPS52 [trans-Golgi network membrane] (R-HSA-6811029)	0.696	5
UniProt:Q9BRK4 LZTS2			0.696	5
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.696	5
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.696	5
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.696	5
UniProt:Q969G2 LHX4	1	LHX4 [nucleoplasm] (R-HSA-9010585)	0.556	3
UniProt:Q8IYA8 IHO1			0.556	3
UniProt:Q8ND90 PNMA1			0.556	3
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845)	0.556	3
UniProt:Q96JN2-2 CCDC136			0.556	3
UniProt:I6L9F6 I6L9F6			0.556	3
UniProt:Q9UJC3 HOOK1			0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:Q2TAC2 CCD57			0.556	3
UniProt:Q9BVG8 KIFC3			0.556	3
UniProt:Q9H596 DUS21			0.488	2
UniProt:Q92764 KRT35	1	KRT35 [cytosol] (R-HSA-6809595)	0.488	2
UniProt:Q9BSW2 CRACR2A	2	CRACR2A [specific granule lumen] (R-HSA-6799553) CRACR2A [extracellular region] (R-HSA-6806289)	0.488	2
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.488	2
UniProt:P35609 ACTN2	3	ACTN2 [platelet alpha granule lumen] (R-HSA-349727) ACTN2 [cytosol] (R-HSA-390562) ACTN2 [extracellular region] (R-HSA-349725)	0.488	2
UniProt:Q5TA45 INTS11	1	CPSF3L [nucleoplasm] (R-HSA-6807411)	0.488	2
UniProt:O75564-2 O755642			0.488	2
UniProt:Q9UBR4-2 LHX3			0.488	2
UniProt:Q13137 CACO2			0.488	2
UniProt:Q7Z3Y8 KRT27	1	KRT27 [cytosol] (R-HSA-6809587)	0.488	2
UniProt:Q5JR59-3 MTUS2			0.488	2
UniProt:O60504 SORBS3	1	SORBS3 [cytosol] (R-HSA-445805)	0.488	2
UniProt:Q58EX7 PKHG4			0.488	2
UniProt:Q14451-3 GRB7			0.488	2
UniProt:Q9GZV8 PRDM14	1	PRDM14 [nucleoplasm] (R-HSA-1112608)	0.488	2
UniProt:Q9UK41-2 VPS28			0.488	2
UniProt:Q08117-2 AES			0.488	2
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.488	2
UniProt:Q9NRA8 4ET			0.488	2
UniProt:Q13084 MRPL28	1	MRPL28 [mitochondrial inner membrane] (R-HSA-5368246)	0.488	2
UniProt:Q8N9I9 DTX3			0.488	2
UniProt:A6NC98 CC88B			0.488	2
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.488	2
UniProt:A2RRN7 A2RRN7			0.488	2
UniProt:Q8WWB3 DYDC1			0.488	2
UniProt:Q15654 TRIP6			0.488	2
UniProt:Q6MZQ0 PRR5L			0.488	2
UniProt:Q13077 TRAF1	3	TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1 [cytosol] (R-HSA-5634163) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.488	2
UniProt:Q9UKT9 IKZF3			0.488	2
UniProt:P60903 S100A10	1	S100A10 [external side of plasma membrane] (R-HSA-5336168)	0.488	2
UniProt:Q96CA5 BIRC7			0.488	2
UniProt:Q8WW24 TEKT4			0.488	2
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.488	2
UniProt:Q15276 RABEP1	1	RABEP1 [early endosome membrane] (R-HSA-2029004)	0.488	2
UniProt:P36406 TRI23			0.488	2
UniProt:Q8WTU0 DDI1			0.488	2
UniProt:Q03169 TNAP2			0.488	2
UniProt:Q86V38 Q86V38			0.488	2
UniProt:A6NEM1 GG6L9			0.488	2
UniProt:Q674X7-2 KAZN			0.488	2
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.488	2
UniProt:Q9NYB9-2 ABI2			0.488	2
UniProt:Q16633 OBF1			0.488	2
UniProt:Q99932-2 SPAG8			0.488	2
UniProt:P57678 GEMIN4	2	GEMIN4 [cytosol] (R-HSA-191836) GEMIN4 [nucleoplasm] (R-HSA-191841)	0.488	2
UniProt:Q6PI77 BHLH9			0.488	2
UniProt:O75140-2 DEPDC5			0.488	2
UniProt:Q9UJV3-2 MID2			0.488	2
UniProt:Q70EL1-9 USP54			0.488	2
UniProt:Q96MT8-3 CEP63			0.488	2
UniProt:Q75MW2-2 ZNF767P			0.488	2
UniProt:Q9H257-2 CARD9			0.488	2
UniProt:Q4G0R1 Q4G0R1			0.488	2
UniProt:Q9NZV7 ZIM2	1	ZIM2 [nucleoplasm] (R-HSA-974996)	0.488	2
UniProt:Q59EK9-3 RUNDC3A			0.488	2
UniProt:Q9NRI5-2 DISC1			0.488	2
UniProt:Q96ED9-2 HOOK2			0.488	2
UniProt:Q08043 ACTN3	1	ACTN3 [cytosol] (R-HSA-390565)	0.488	2
UniProt:P51692 STAT5B	5	p-STAT5B [cytosol] (R-HSA-8983127) p-STAT5B [nucleoplasm] (R-HSA-8982834) STAT5B [cytosol] (R-HSA-380737) p-Y699-STAT5B [nucleoplasm] (R-HSA-508016) p-Y699-STAT5B [cytosol] (R-HSA-507939)	0.488	2
UniProt:Q4V328 GRAP1			0.488	2
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.488	2
UniProt:Q96N16 JKIP1			0.488	2
UniProt:Q5VZ52 MORN5			0.488	2
UniProt:A6NLX3 SPDE4			0.488	2
UniProt:Q96B26 EXOSC8	2	EXOSC8 [cytosol] (R-HSA-429912) EXOSC8 [nucleoplasm] (R-HSA-6791571)	0.488	2
UniProt:Q14525 KRT33B	1	KRT33B [cytosol] (R-HSA-6809594)	0.488	2
UniProt:Q8HWS3 RFX6	1	RFX6 [nucleoplasm] (R-HSA-8931801)	0.488	2
UniProt:Q8N6Y0 USBP1			0.488	2
IntAct:EBI-11957832 CCDC136			0.488	2
UniProt:Q8N4Y2-3 CRACR2B			0.488	2
UniProt:P12814 ACTN1	3	ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [cytosol] (R-HSA-354096) ACTN1 [extracellular region] (R-HSA-349722)	0.488	2
UniProt:O14492-2 O144922			0.488	2
UniProt:Q5JST6 EFHC2			0.488	2
UniProt:Q9NYA3 GOG6A			0.488	2
UniProt:Q8TD16-2 BICD2			0.488	2
UniProt:Q03252 LMNB2			0.488	2
UniProt:Q86XT4 TRIM50	1	TRIM50 [cytosol] (R-HSA-5688976)	0.488	2
UniProt:Q9BVG8-5 KIFC3			0.488	2
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.488	2
UniProt:Q15742 NAB2			0.488	2
IntAct:EBI-18099268 BCL2L2PABPN1			0.488	2
UniProt:P56945 BCAR1	4	p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y-BCAR1 [cytosol] (R-HSA-372645) BCAR1 [cytosol] (R-HSA-201625) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723)	0.488	2
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.488	2
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.488	2
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.488	2
UniProt:Q96CV9 OPTN	4	p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.488	2
UniProt:Q86U10 ASPG	1	ASPG [cytosol] (R-HSA-6797634)	0.488	2
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-5623383) EXOC5 [cytosol] (R-HSA-265045)	0.488	2