Reactome | USP2 [nucleoplasm]

USP2 [nucleoplasm]

Stable Identifier

R-HSA-5689946

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O75604 USP2

Gene Names

USP2, UBP41

Chain

chain:1-605

Reference Genes

BioGPS Gene:9099 USP2

COSMIC (genes):USP2 USP2

CTD Gene:9099 USP2

dbSNP Gene:9099 USP2

ENSEMBL:ENSG00000036672 USP2

HGNC:12618 USP2

KEGG Gene (Homo sapiens):9099 USP2

Monarch:9099 USP2

NCBI Gene:9099 USP2

OMIM:604725 USP2

UCSC:O75604 USP2

Reference Transcript

Other Identifiers

0003440156

0003440341

0005270184

11724044_a_at

11724045_a_at

11740198_a_at

16745343

207213_s_at

229337_at

230965_at

3394355

3394357

3394358

3394360

3394361

3394362

3394365

3394367

3394368

3394370

3394371

3394373

3394374

3394375

3394378

3394379

3394387

3394388

3394397

3394398

3394399

34901_at

56580_at

7952249

90053_at

9099

A_23_P24966

A_24_P107317

GE54715

GE56913

GO:0000122

GO:0000278

GO:0003674

GO:0004197

GO:0004843

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005856

GO:0006464

GO:0006508

GO:0006511

GO:0007049

GO:0007517

GO:0008150

GO:0008233

GO:0008234

GO:0009056

GO:0009058

GO:0016020

GO:0016579

GO:0016787

GO:0019899

GO:0030332

GO:0031625

GO:0032922

GO:0034641

GO:0036459

GO:0042802

GO:0043153

GO:0043167

GO:0043226

GO:0045475

GO:0045931

GO:0046872

GO:0048471

GO:0048511

GO:0048512

GO:0048856

GO:0050821

Hs.125877.0.A1_3p_at

Hs.125877.0.A1_3p_x_at

Hs.23690.0.A1_3p_at

ILMN_1653940

ILMN_1705627

ILMN_1755502

PH_hs_0007134

TC11002370.hg

g4759291_3p_a_at

Participant Of

output

USP2 deubiquitinates MDM2,MDM4

hasComponent

USP2:PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm]

input

USP2 binds the heterodimer of MDM2 and MDM4

Other forms of this molecule

USP2 [cytosol]

Inferred To

Usp2 [nucleoplasm] (Drosophila melanogaster)

Homologues of USP2 [nucleoplasm] (Dictyostelium discoideum)

Homologues of USP2 [nucleoplasm] (Plasmodium falciparum)

cyk-3 [nucleoplasm] (Caenorhabditis elegans)

usp2a [nucleoplasm] (Danio rerio)

USP2 [nucleoplasm] (Bos taurus)

USP2 [nucleoplasm] (Canis familiaris)

USP2 [nucleoplasm] (Dictyostelium discoideum)

USP2 [nucleoplasm] (Gallus gallus)

USP2 [nucleoplasm] (Plasmodium falciparum)

USP2 [nucleoplasm] (Sus scrofa)

usp2 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_004196.4, XP_005271779.1, NP_001230688.1, NP_741994.1, XP_005271778.1

OpenTargets

ENSG00000036672

IntEnz

3.4.19.12

HPA

ENSG00000036672-USP2

GeneCards

O75604

ZINC target

O75604

Ensembl

ENST00000525735, ENSG00000036672, ENSP00000407842, ENST00000260187, ENSP00000260187, ENST00000455332, ENSP00000436952

PRO

O75604

HMDB Protein

HMDBP11576

PDB

3V6E, 6DGF, 5XVE, 2HD5, 3NHE, 5XU8, 3V6C, 2IBI

Interactors (106)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.781	7
UniProt:Q9GZM8 NDEL1	1	NDEL1 [cytosol] (R-HSA-376258)	0.718	6
UniProt:Q9NSC5 HOMER3	1	HOMER3 [cytosol] (R-HSA-6794236)	0.718	6
UniProt:Q8N1B4 VPS52	1	VPS52 [trans-Golgi network membrane] (R-HSA-6811029)	0.718	6
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.718	6
UniProt:Q9BRK4 LZTS2			0.718	6
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.718	6
UniProt:P19012 KRT15	1	KRT15 [cytosol] (R-HSA-6809589)	0.703	5
UniProt:Q969G2 LHX4	1	LHX4 [nucleoplasm] (R-HSA-9010585)	0.666	4
UniProt:Q9H596 DUS21			0.556	3
UniProt:Q9BSW2 CRACR2A	2	CRACR2A [specific granule lumen] (R-HSA-6799553) CRACR2A [extracellular region] (R-HSA-6806289)	0.556	3
UniProt:Q92764 KRT35	1	KRT35 [cytosol] (R-HSA-6809595)	0.556	3
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.556	3
IntAct:EBI-23194311 CCSB ORF ID			0.556	3
UniProt:P35609 ACTN2	3	ACTN2 [platelet alpha granule lumen] (R-HSA-349727) ACTN2 [cytosol] (R-HSA-390562) ACTN2 [extracellular region] (R-HSA-349725)	0.556	3
UniProt:Q8IYA8 IHO1			0.556	3
UniProt:Q5TA45 INTS11	1	CPSF3L [nucleoplasm] (R-HSA-6807411)	0.556	3
UniProt:O75564-2 O755642			0.556	3
UniProt:Q9UBR4-2 LHX3			0.556	3
UniProt:Q8ND90 PNMA1			0.556	3
UniProt:Q13137 CACO2			0.556	3
UniProt:Q7Z3Y8 KRT27	1	KRT27 [cytosol] (R-HSA-6809587)	0.556	3
UniProt:Q5JR59-3 MTUS2			0.556	3
UniProt:O60504 SORBS3	1	SORBS3 [cytosol] (R-HSA-445805)	0.556	3
UniProt:Q58EX7 PKHG4			0.556	3
UniProt:Q14451-3 GRB7			0.556	3
UniProt:P56945 BCAR1	4	p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y-BCAR1 [cytosol] (R-HSA-372645) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) BCAR1 [cytosol] (R-HSA-201625)	0.556	3
UniProt:Q08117-2 TLE5			0.556	5
UniProt:Q9UK41-2 VPS28			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q9NRA8 4ET			0.556	3
UniProt:Q13084 MRPL28	1	MRPL28 [mitochondrial inner membrane] (R-HSA-5368246)	0.556	3
UniProt:Q8N9I9 DTX3			0.556	3
UniProt:A6NC98 CC88B			0.556	3
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [plasma membrane] (R-HSA-936955) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845)	0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:A2RRN7 A2RRN7			0.556	3
UniProt:Q8WWB3 DYDC1			0.556	3
UniProt:Q15654 TRIP6			0.556	3
UniProt:Q6MZQ0 PRR5L			0.556	3
UniProt:Q13077 TRAF1	3	TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1 [cytosol] (R-HSA-5634163) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:P60903 S100A10	1	S100A10 [external side of plasma membrane] (R-HSA-5336168)	0.556	3
UniProt:Q96CA5 BIRC7			0.556	3
UniProt:Q8WW24 TEKT4			0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:Q96JN2-2 CCDC136			0.556	3
UniProt:Q15276 RABEP1	1	RABEP1 [early endosome membrane] (R-HSA-2029004)	0.556	3
UniProt:I6L9F6 I6L9F6			0.556	3
UniProt:P36406 TRI23			0.556	3
UniProt:Q9UJC3 HOOK1			0.556	3
UniProt:Q8WTU0 DDI1			0.556	3
IntAct:EBI-16435328 CCSB ORF ID			0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.556	3
UniProt:Q03169 TNAP2			0.556	3
UniProt:Q86V38 Q86V38			0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:Q674X7-2 KAZN			0.556	3
UniProt:Q2TAC2 CCD57			0.556	3
UniProt:Q86U10 ASPG	1	ASPG [cytosol] (R-HSA-6797634)	0.556	3
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.556	3
UniProt:Q9NYB9-2 ABI2			0.556	3
UniProt:Q16633 OBF1			0.556	3
UniProt:Q99932-2 SPAG8			0.556	3
UniProt:P57678 GEMIN4	2	GEMIN4 [cytosol] (R-HSA-191836) GEMIN4 [nucleoplasm] (R-HSA-191841)	0.556	3
UniProt:Q6PI77 BHLH9			0.556	3
UniProt:Q9UJV3-2 MID2			0.556	3
UniProt:O75140-2 DEPDC5			0.556	3
UniProt:Q70EL1-9 USP54			0.556	3
UniProt:Q96MT8-3 CEP63			0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.556	3
UniProt:Q9H257-2 CARD9			0.556	3
UniProt:Q4G0R1 Q4G0R1			0.556	3
UniProt:Q9NZV7 ZIM2	1	ZIM2 [nucleoplasm] (R-HSA-974996)	0.556	3
UniProt:Q59EK9-3 RUNDC3A			0.556	3
UniProt:Q9NRI5-2 DISC1			0.556	3
UniProt:Q96ED9-2 HOOK2			0.556	3
UniProt:Q08043 ACTN3	1	ACTN3 [cytosol] (R-HSA-390565)	0.556	3
UniProt:P51692 STAT5B	5	p-STAT5B [cytosol] (R-HSA-8983127) p-STAT5B [nucleoplasm] (R-HSA-8982834) p-Y699-STAT5B [nucleoplasm] (R-HSA-508016) p-Y699-STAT5B [cytosol] (R-HSA-507939) STAT5B [cytosol] (R-HSA-380737)	0.556	3
UniProt:Q4V328 GRAP1			0.556	3
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-5623383) EXOC5 [cytosol] (R-HSA-265045)	0.556	3
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.556	3
UniProt:Q96N16 JKIP1			0.556	3
UniProt:Q5VZ52 MORN5			0.556	3
UniProt:A6NLX3 SPDE4			0.556	3
UniProt:Q96B26 EXOSC8	2	EXOSC8 [cytosol] (R-HSA-429912) EXOSC8 [nucleoplasm] (R-HSA-6791571)	0.556	3
UniProt:Q14525 KRT33B	1	KRT33B [cytosol] (R-HSA-6809594)	0.556	3
UniProt:Q8HWS3 RFX6	1	RFX6 [nucleoplasm] (R-HSA-8931801)	0.556	3
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:Q9BVG8 KIFC3			0.556	3
UniProt:Q8N4Y2-3 CRACR2B			0.556	3
UniProt:P12814 ACTN1	3	ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [cytosol] (R-HSA-354096) ACTN1 [extracellular region] (R-HSA-349722)	0.556	3
UniProt:O14492-2 O144922			0.556	3
UniProt:Q5JST6 EFHC2			0.556	3
UniProt:Q9NYA3 GOG6A			0.556	3
UniProt:Q03252 LMNB2			0.556	3
UniProt:Q8TD16-2 BICD2			0.556	3
UniProt:Q86XT4 TRIM50	1	TRIM50 [cytosol] (R-HSA-5688976)	0.556	3
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:Q96CV9 OPTN	4	OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525)	0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:Q9GZV8 PRDM14	1	PRDM14 [nucleoplasm] (R-HSA-1112608)	0.556	3

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