Reactome | USP2 [nucleoplasm]

USP2 [nucleoplasm]

Stable Identifier

R-HSA-5689946

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O75604 USP2

Gene Names

USP2, UBP41

Chain

chain:1-605

Reference Genes

BioGPS Gene:9099 USP2

COSMIC (genes):USP2 USP2

CTD Gene:9099 USP2

dbSNP Gene:9099 USP2

ENSEMBL:ENSG00000036672 USP2

HGNC:12618 USP2

KEGG Gene (Homo sapiens):9099 USP2

Monarch:9099 USP2

NCBI Gene:9099 USP2

OMIM:604725 USP2

UCSC:O75604 USP2

Reference Transcript

Other Identifiers

0003440156

0003440341

0005270184

11724044_a_at

11724045_a_at

11740198_a_at

16745343

207213_s_at

229337_at

230965_at

3394355

3394357

3394358

3394360

3394361

3394362

3394365

3394367

3394368

3394370

3394371

3394373

3394374

3394375

3394378

3394379

3394387

3394388

3394397

3394398

3394399

34901_at

56580_at

7952249

90053_at

9099

A_23_P24966

A_24_P107317

GE54715

GE56913

GO:0000122

GO:0000278

GO:0003674

GO:0004197

GO:0004843

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005856

GO:0006464

GO:0006508

GO:0006511

GO:0007049

GO:0007517

GO:0008150

GO:0008233

GO:0008234

GO:0009056

GO:0009058

GO:0016020

GO:0016579

GO:0016787

GO:0019899

GO:0030332

GO:0031625

GO:0032922

GO:0034641

GO:0036459

GO:0042802

GO:0043153

GO:0043167

GO:0043226

GO:0045475

GO:0045931

GO:0046872

GO:0048471

GO:0048511

GO:0048512

GO:0048856

GO:0050821

Hs.125877.0.A1_3p_at

Hs.125877.0.A1_3p_x_at

Hs.23690.0.A1_3p_at

ILMN_1653940

ILMN_1705627

ILMN_1755502

PH_hs_0007134

TC11002370.hg

g4759291_3p_a_at

Participant Of

input

USP2 binds the heterodimer of MDM2 and MDM4

output

USP2 deubiquitinates MDM2,MDM4

hasComponent

USP2:PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm]

Other forms of this molecule

USP2 [cytosol]

Inferred To

Usp2 [nucleoplasm] (Drosophila melanogaster)

Homologues of USP2 [nucleoplasm] (Dictyostelium discoideum)

Homologues of USP2 [nucleoplasm] (Plasmodium falciparum)

cyk-3 [nucleoplasm] (Caenorhabditis elegans)

usp2a [nucleoplasm] (Danio rerio)

USP2 [nucleoplasm] (Canis familiaris)

USP2 [nucleoplasm] (Dictyostelium discoideum)

USP2 [nucleoplasm] (Gallus gallus)

USP2 [nucleoplasm] (Plasmodium falciparum)

USP2 [nucleoplasm] (Sus scrofa)

USP2 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_741994.1, XP_005271779.1, NP_001230688.1, XP_005271778.1, NP_004196.4

OpenTargets

ENSG00000036672

IntEnz

3.4.19.12

GeneCards

O75604

HPA

ENSG00000036672-USP2

Ensembl

ENST00000525735, ENSP00000436952, ENST00000455332, ENSG00000036672, ENST00000260187, ENSP00000407842, ENSP00000260187

ZINC target

O75604

PRO

O75604

HMDB Protein

HMDBP11576

PDB

3V6E, 5XU8, 2HD5, 3NHE, 2IBI, 3V6C, 6DGF, 5XVE

Interactors (106)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.781	7
UniProt:Q9GZM8 NDEL1	1	NDEL1 [cytosol] (R-HSA-376258)	0.718	6
UniProt:Q9NSC5 HOMER3	1	HOMER3 [cytosol] (R-HSA-6794236)	0.718	6
UniProt:Q8N1B4 VPS52	1	VPS52 [trans-Golgi network membrane] (R-HSA-6811029)	0.718	6
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.718	6
UniProt:Q9BRK4 LZTS2			0.718	6
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.718	6
UniProt:P19012 KRT15	1	KRT15 [cytosol] (R-HSA-6809589)	0.703	5
UniProt:Q969G2 LHX4	1	LHX4 [nucleoplasm] (R-HSA-9010585)	0.666	4
UniProt:Q9H596 DUS21			0.556	3
UniProt:Q9BSW2 CRACR2A	2	CRACR2A [specific granule lumen] (R-HSA-6799553) CRACR2A [extracellular region] (R-HSA-6806289)	0.556	3
UniProt:Q92764 KRT35	1	KRT35 [cytosol] (R-HSA-6809595)	0.556	3
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.556	3
IntAct:EBI-23194311 CCSB ORF ID			0.556	3
UniProt:P35609 ACTN2	3	ACTN2 [platelet alpha granule lumen] (R-HSA-349727) ACTN2 [cytosol] (R-HSA-390562) ACTN2 [extracellular region] (R-HSA-349725)	0.556	3
UniProt:Q8IYA8 IHO1			0.556	3
UniProt:Q5TA45 INTS11	1	CPSF3L [nucleoplasm] (R-HSA-6807411)	0.556	3
UniProt:O75564-2 O755642			0.556	3
UniProt:Q9UBR4-2 LHX3			0.556	3
UniProt:Q8ND90 PNMA1			0.556	3
UniProt:Q13137 CACO2			0.556	3
UniProt:Q7Z3Y8 KRT27	1	KRT27 [cytosol] (R-HSA-6809587)	0.556	3
UniProt:Q5JR59-3 MTUS2			0.556	3
UniProt:O60504 SORBS3	1	SORBS3 [cytosol] (R-HSA-445805)	0.556	3
UniProt:Q58EX7 PKHG4			0.556	3
UniProt:Q14451-3 GRB7			0.556	3
UniProt:P56945 BCAR1	4	p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y-BCAR1 [cytosol] (R-HSA-372645) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) BCAR1 [cytosol] (R-HSA-201625)	0.556	3
UniProt:Q9GZV8 PRDM14	1	PRDM14 [nucleoplasm] (R-HSA-1112608)	0.556	3
UniProt:Q08117-2 TLE5			0.556	5
UniProt:Q9UK41-2 VPS28			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q9NRA8 4ET			0.556	3
UniProt:Q13084 MRPL28	1	MRPL28 [mitochondrial inner membrane] (R-HSA-5368246)	0.556	3
UniProt:Q8N9I9 DTX3			0.556	3
UniProt:A6NC98 CC88B			0.556	3
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845)	0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:A2RRN7 A2RRN7			0.556	3
UniProt:Q8WWB3 DYDC1			0.556	3
UniProt:Q15654 TRIP6			0.556	3
UniProt:Q6MZQ0 PRR5L			0.556	3
UniProt:Q13077 TRAF1	3	TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1 [cytosol] (R-HSA-5634163) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:P60903 S100A10	1	S100A10 [external side of plasma membrane] (R-HSA-5336168)	0.556	3
UniProt:Q96CA5 BIRC7			0.556	3
UniProt:Q8WW24 TEKT4			0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:Q96JN2-2 CCDC136			0.556	3
UniProt:Q15276 RABEP1	1	RABEP1 [early endosome membrane] (R-HSA-2029004)	0.556	3
UniProt:I6L9F6 I6L9F6			0.556	3
UniProt:P36406 TRI23			0.556	3
UniProt:Q9UJC3 HOOK1			0.556	3
UniProt:Q8WTU0 DDI1			0.556	3
IntAct:EBI-16435328 CCSB ORF ID			0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.556	3
UniProt:Q03169 TNAP2			0.556	3
UniProt:Q86V38 Q86V38			0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:Q674X7-2 KAZN			0.556	3
UniProt:Q2TAC2 CCD57			0.556	3
UniProt:Q86U10 ASPG	1	ASPG [cytosol] (R-HSA-6797634)	0.556	3
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.556	3
UniProt:Q9NYB9-2 ABI2			0.556	3
UniProt:Q16633 OBF1			0.556	3
UniProt:Q99932-2 SPAG8			0.556	3
UniProt:P57678 GEMIN4	2	GEMIN4 [cytosol] (R-HSA-191836) GEMIN4 [nucleoplasm] (R-HSA-191841)	0.556	3
UniProt:Q6PI77 BHLH9			0.556	3
UniProt:Q9UJV3-2 MID2			0.556	3
UniProt:O75140-2 DEPDC5			0.556	3
UniProt:Q70EL1-9 USP54			0.556	3
UniProt:Q96MT8-3 CEP63			0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.556	3
UniProt:Q9H257-2 CARD9			0.556	3
UniProt:Q4G0R1 Q4G0R1			0.556	3
UniProt:Q9NZV7 ZIM2	1	ZIM2 [nucleoplasm] (R-HSA-974996)	0.556	3
UniProt:Q59EK9-3 RUNDC3A			0.556	3
UniProt:Q9NRI5-2 DISC1			0.556	3
UniProt:Q96ED9-2 HOOK2			0.556	3
UniProt:Q08043 ACTN3	1	ACTN3 [cytosol] (R-HSA-390565)	0.556	3
UniProt:P51692 STAT5B	5	p-STAT5B [cytosol] (R-HSA-8983127) p-STAT5B [nucleoplasm] (R-HSA-8982834) p-Y699-STAT5B [nucleoplasm] (R-HSA-508016) p-Y699-STAT5B [cytosol] (R-HSA-507939) STAT5B [cytosol] (R-HSA-380737)	0.556	3
UniProt:Q4V328 GRAP1			0.556	3
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.556	3
UniProt:Q96N16 JKIP1			0.556	3
UniProt:Q5VZ52 MORN5			0.556	3
UniProt:A6NLX3 SPDE4			0.556	3
UniProt:Q96B26 EXOSC8	2	EXOSC8 [cytosol] (R-HSA-429912) EXOSC8 [nucleoplasm] (R-HSA-6791571)	0.556	3
UniProt:Q14525 KRT33B	1	KRT33B [cytosol] (R-HSA-6809594)	0.556	3
UniProt:Q8HWS3 RFX6	1	RFX6 [nucleoplasm] (R-HSA-8931801)	0.556	3
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:Q9BVG8 KIFC3			0.556	3
UniProt:Q8N4Y2-3 CRACR2B			0.556	3
UniProt:P12814 ACTN1	3	ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [cytosol] (R-HSA-354096) ACTN1 [extracellular region] (R-HSA-349722)	0.556	3
UniProt:O14492-2 O144922			0.556	3
UniProt:Q5JST6 EFHC2			0.556	3
UniProt:Q9NYA3 GOG6A			0.556	3
UniProt:Q03252 LMNB2			0.556	3
UniProt:Q8TD16-2 BICD2			0.556	3
UniProt:Q86XT4 TRIM50	1	TRIM50 [cytosol] (R-HSA-5688976)	0.556	3
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:Q96CV9 OPTN	4	OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525)	0.556	3
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-5623383) EXOC5 [cytosol] (R-HSA-265045)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3

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