USP2 deubiquitinates MDM2,MDM4

Stable Identifier
R-HSA-5689972
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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USP2 deubiquitinates MDM2,MDM4
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The ubiquitin protease USP2 deubiquitinates MDM2 and MDM4 but not TP53 (Stevenson et al. 2007, Allende-Vega et al. 2010).

Literature References
PubMed ID Title Journal Year
17290220 The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

Stevenson, LF, Sparks, A, Allende-Vega, N, Xirodimas, DP, Lane, DP, Saville, MK

EMBO J. 2007
19838211 MdmX is a substrate for the deubiquitinating enzyme USP2a

Allende-Vega, N, Sparks, A, Lane, DP, Saville, MK

Oncogene 2010
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP2:PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm]
Physical Entity
USP2:PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm]
Activity
thiol-dependent ubiquitinyl hydrolase activity (0036459)
Orthologous Events
USP2 deubiquitinates MDM2,MDM4 (Bos taurus)
USP2 deubiquitinates MDM2,MDM4 (Canis familiaris)
USP2 deubiquitinates MDM2,MDM4 (Danio rerio)
USP2 deubiquitinates MDM2,MDM4 (Drosophila melanogaster)
USP2 deubiquitinates MDM2,MDM4 (Mus musculus)
USP2 deubiquitinates MDM2,MDM4 (Rattus norvegicus)
USP2 deubiquitinates MDM2,MDM4 (Sus scrofa)
USP2 deubiquitinates MDM2,MDM4 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Jupe, S  (2015-04-27)