Reactome | PPT2 hydrolyses PALMCoA to PALM

PPT2 hydrolyses PALMCoA to PALM

Stable Identifier

R-HSA-5690046

Type

Reaction [transition]

Species

Homo sapiens

Compartment

lysosomal lumen

ReviewStatus

5/5

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The maintenance/regulation of cellular levels of free fatty acids and fatty acyl-CoAs (the activated form of free fatty acids) is extremely important, as imbalances in lipid metabolism can have serious consequences for human health. Free fatty acids can act as detergents to disrupt membranes so their generation is normally tightly regulated to states where they will be rapidly consumed or sequestered. Acyl-coenzyme A thioesterases (ACOTs) hydrolyse the thioester bond in medium- to long-chain fatty acyl-CoAs (of C12-C18 lengths) (MCFAcylCoA, LCFAcylCoA) to their free fatty acids (MCFA, LCFA) (Cohen 2013, Hunt et al. 2012, Kirkby et al. 2010). Lysosomal thioesterase PPT2 is able to specifically hydrolyse palmitoyl-CoA (PALM-CoA) to palmitic acid (PALM) (Soyombo & Hofmann 1997).

Literature References

PubMed ID	Title	Journal	Year
20470824	Functional and structural properties of mammalian acyl-coenzyme A thioesterases Forwood, JK, Kobe, B, Roman, N, Kirkby, B, Kellie, S	Prog. Lipid Res.	2010
9341199	Molecular cloning and expression of palmitoyl-protein thioesterase 2 (PPT2), a homolog of lysosomal palmitoyl-protein thioesterase with a distinct substrate specificity Soyombo, AA, Hofmann, SL	J. Biol. Chem.	1997
22465940	The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism Alexson, SE, Siponen, MI, Hunt, MC	Biochim. Biophys. Acta	2012
23700546	New players on the metabolic stage: How do you like Them Acots? Cohen, DE	Adipocyte	2013