Reactome | USP21 deubiquitinates RIPK1,DDX58

USP21 deubiquitinates RIPK1,DDX58

Stable Identifier

R-HSA-5690159

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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USP21 is not required for normal development (Pannu et al. 2015) but is essential in innate and adaptive immune responses (Tao et al. 2014). It negatively regulates NFkB signaling by deubiquitinating Receptor-interacting protein 1 (RIPK1) (Xu et al. 2010) and DDX58 (RIG-I), thereby down-regulating antiviral responses independently of the A20 ubiquitin-editing complex (Fan et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
24493797	USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase Fan, Y, Zhang, D, Jung, JU, Chen, Z, An, L, Mao, R, Yang, J, Li, X, Xu, G, Cheng, J, Zhang, H, Zhao, Y, Liu, S, Xu, X, Yu, Y, Zhang, H, Shi, Z, Zhang, P, Kogiso, M	J. Exp. Med.	2014
19910467	Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1 Cao, G, Xu, G, Gu, X, Wang, H, Shi, Y, Tan, X, Sun, W, Zhang, T, Yang, J, Qin, J, Burlingame, S	J. Biol. Chem.	2010