p-T182-MAPKAPK5 phoshphorylates DNAJB1

Stable Identifier
R-HSA-5690250
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated MAPKAPK5 phosphorylates HSP40/DNAJB1 at serines 149, 151 and 171, promoting the ATP hydrolysis activity of the HSP40/HSP70 complex and enhancing the repression of heat shock factor 1 (HSF1) driven transcription by HSP40/DNAJB1 (Kostenko et al, 2014).

Literature References
PubMed ID Title Journal Year
24309468 Phosphorylation of heat shock protein 40 (Hsp40/DnaJB1) by mitogen-activated protein kinase-activated protein kinase 5 (MK5/PRAK)

Kostenko, S, Jensen, KL, Moens, U

Int. J. Biochem. Cell Biol. 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T182 MAPKAPK5:DNAJB1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!