Negative regulation by 'PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane]'

Stable Identifier
R-HSA-5690718
Type
NegativeRegulation
Locations in the PathwayBrowser
Summation

SHP1 regulates BCR signaling by dephosphorylating CD79A/CD79B (IGA/IGB) and its downstream signaling molecules SYK and SLP65 promoting Ca2+ efflux from the cell9 (Adachi et al. 2001, Chen et al. 2004).

Literature References
PubMed ID Title Journal Year
23836650 CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca2+ signaling Proc. Natl. Acad. Sci. U.S.A. 2013
Regulation participants
Regulation type
NegativeRegulation