Reactome: A Curated Pathway Database

'PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane]' negatively regulates 'FYN, LYN, BLK-like proteins phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)'

Stable Identifier
R-HSA-5690718
Type
NegativeRegulation
Locations in the PathwayBrowser
Summation

SHP1 regulates BCR signaling by dephosphorylating CD79A/CD79B (IGA/IGB) and its downstream signaling molecules SYK and SLP65 promoting Ca2+ efflux from the cell9 (Adachi et al. 2001, Chen et al. 2004).

Literature References
PubMed ID Title Journal Year
Regulation participants
Regulation type
NegativeRegulation