Histone H2A is dubiquitinated by the PR-DUB complex

Stable Identifier
R-HSA-5690790
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

BAP1 is the catalytic component of the PR-DUB complex, which deubiquitinates Lysine-120 monoubiquitinated Histone H2A (H2AK119ub1) (Scheuermann et al. 2010). The PR-DUB complex consists of BAP1, ASXL1/2, KDM1B, FOXK1/2, HCFC1 and MBD5/6 (Yu et al. 2010, Dey et al. 2012, Baymaz et al. 2014).

Literature References
PubMed ID Title Journal Year
20436459 Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

Scheuermann, JC, de Ayala Alonso, AG, Oktaba, K, Ly-Hartig, N, McGinty, RK, Fraterman, S, Wilm, M, Muir, TW, Müller, J

Nature 2010
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of PR-DUB complex [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed