Histone H2A is dubiquitinated by the PR-DUB complex

Stable Identifier
R-HSA-5690790
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

BAP1 is the catalytic component of the PR-DUB complex, which deubiquitinates Lysine-120 monoubiquitinated Histone H2A (H2AK119ub1) (Scheuermann et al. 2010). The PR-DUB complex consists of BAP1, ASXL1/2, KDM1B, FOXK1/2, HCFC1 and MBD5/6 (Yu et al. 2010, Dey et al. 2012, Baymaz et al. 2014).

Literature References
PubMed ID Title Journal Year
20436459 Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

Scheuermann, JC, de Ayala Alonso, AG, Oktaba, K, Ly-Hartig, N, McGinty, RK, Fraterman, S, Wilm, M, Muir, TW, Müller, J

Nature 2010
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of PR-DUB complex [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created