UCHL3, SENP8 cleave NEDD8

Stable Identifier
R-HSA-5690808
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

UCHL3 and SENP8 (DEN1) remove the C-terminal extension of NEDD8 propeptides, exposing a C-terminal Gly residue. UCHL3 can also process ubiquitin (Wada et al. 1998). UCHL3 and SENP8 are probably functionally redundant in NEDD8 processing as deletion of either enzyme does not lead to neddylation defects (Chan et al. 2008, Kurihara et al. 2000).

Literature References
PubMed ID Title Journal Year
9790970 Cleavage of the C-terminus of NEDD8 by UCH-L3 Biochem. Biophys. Res. Commun. 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
NEDD8-specific protease activity of UCHL3,SENP8:NEDD8(1-88) [cytosol]
Physical Entity
Activity
Orthologous Events