Reactome | K48polyUb,K63polyUb-HCFC1 [nucleoplasm]

K48polyUb,K63polyUb-HCFC1 [nucleoplasm]

Stable Identifier

R-HSA-5690821

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Host cell factor 1, HCFC1_HUMAN, HCF1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P51610 HCFC1

Gene Names

HCFC1, HCF1, HFC1

Chain

initiator methionine:, chain:2-1423, chain:2-1323, chain:2-1295, chain:2-1110, chain:2-1081, chain:2-1019, chain:1020-2035, chain:1082-2035, chain:1111-2035, chain:1296-2035, chain:1324-2035, chain:1424-2035

Reference Genes

BioGPS Gene:3054 HCFC1

COSMIC (genes):HCFC1 HCFC1

CTD Gene:3054 HCFC1

dbSNP Gene:3054 HCFC1

ENSEMBL:ENSG00000172534 HCFC1

HGNC:4839 HCFC1

KEGG:hsa:3054 HCFC1

Monarch:3054 HCFC1

NCBI Gene:3054 HCFC1

OMIM:300019 HCFC1

UCSC:P51610 HCFC1

Reference Transcript

Participates

as an input of

BAP1 binds Ub-HCFC1 (Homo sapiens)

as a component of

BAP1:K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

HCFC1 [nucleoplasm]

Inferred To

HCFC1 [nucleoplasm] (Bos taurus)

HCFC1 [nucleoplasm] (Canis familiaris)

HCFC1 [nucleoplasm] (Sus scrofa)

Homologues of K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (Rattus norvegicus)

Hcfc1 [nucleoplasm] (Mus musculus)

Hcfc1 [nucleoplasm] (Rattus norvegicus)

Hcf [nucleoplasm] (Drosophila melanogaster)

Modified Residues

Name

ubiquitinylated lysine (K48-polyUb, K63-polyUb [nucleoplasm]) at 1807

Coordinate

1807

Modification

K48-polyUb, K63-polyUb [nucleoplasm]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

ENSEMBL

ENSP00000309555, ENST00000310441, ENSG00000172534

OpenTargets

ENSG00000172534

HPA

ENSG00000172534-HCFC1

GeneCards

HCFC1

PRO

P51610

Pharos - Targets

P51610

GlyGen

P51610

Orphanet

HCFC1

PDB

4N39, 4N3A, 6MA1, 5LWV, 4N3B, 6MA5, 6MA4, 6MA3, 6MA2, 4N3C, 4GO6

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.803	7
UniProt:O43889 CREB3	7	CREB3(1-256) [nucleoplasm] (R-HSA-8874190) CREB3(1-256) [cytosol] (R-HSA-8874135) CREB3(1-291) [Golgi membrane] (R-HSA-8874181) CREB3(257-291) [Golgi membrane] (R-HSA-8874207) CREB3 [Golgi membrane] (R-HSA-8874123) CREB3(292-371) [Golgi membrane] (R-HSA-8874173) CREB3 [endoplasmic reticulum membrane] (R-HSA-8874165)	0.802	7
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.773	6
UniProt:Q9NS37 ZHANG			0.766	8
UniProt:O15294 OGT	2	OGT [cytosol] (R-HSA-9687814) OGT [nucleoplasm] (R-HSA-3321845)	0.764	10
UniProt:Q92560 BAP1	1	BAP1 [nucleoplasm] (R-HSA-5689665)	0.744	6
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.681	4
UniProt:O43889-2 CREB3			0.658	4
UniProt:Q96EK4 THA11			0.632	4
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.605	6
UniProt:Q13105 ZBTB17	1	ZBTB17 [nucleoplasm] (R-HSA-535577)	0.581	9
UniProt:Q9NVV9 THAP1			0.567	6
UniProt:Q9D1P2	1	KAT8 [nucleoplasm] (R-MMU-3321802)	0.564	2
UniProt:Q9BTC0 DIDO1			0.564	3
UniProt:P14316 IRF2	2	IRF2 [cytosol] (R-HSA-1015681) IRF2 [nucleoplasm] (R-HSA-994031)	0.527	2
UniProt:Q03164 KMT2A	6	KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A [cytosol] (R-HSA-9818584)	0.527	2
UniProt:Q96LX8 ZNF597	1	ZNF597 [nucleoplasm] (R-HSA-2127591)	0.527	2
UniProt:Q06547-2 GABPB1	1	NRF2 beta-2 subunit [nucleoplasm] (R-HSA-1592200)	0.508	6
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.499	2
UniProt:Q9H7L9 SUDS3	2	K63polyUb-SUDS3 [nucleoplasm] (R-HSA-6782790) SUDS3 [nucleoplasm] (R-HSA-351696)	0.499	2
UniProt:P51610 HCFC1	2	HCFC1 [nucleoplasm] (R-HSA-1592209) K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821)	0.499	2
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.499	2
UniProt:O15047 SETD1A	1	SETD1A [nucleoplasm] (R-HSA-3239027)	0.499	2
UniProt:Q06546 GABPA	1	GABPA [nucleoplasm] (R-HSA-1592206)	0.499	2
UniProt:Q06547 GABPB1			0.499	3
UniProt:Q16630 CPSF6	2	CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838987) CPSF6(1-490)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614368)	0.483	2
UniProt:Q9P0U4 CXXC1	1	CXXC1 [nucleoplasm] (R-HSA-535610)	0.462	2
UniProt:Q9H4Z2 ZNF335	1	ZNF335 [nucleoplasm] (R-HSA-6810129)	0.462	2

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