TNFAIP3 (A20) ubiquitinates RIPK1

Stable Identifier
R-HSA-5690827
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The carboxy-terminal domain of TNFAIP3 (A20) functions as a ubiquitin ligase, polyubiquitinating RIPK1 with K48-linked ubiquitin chains, thereby targeting it for proteasomal degradation (Wertz et al. 2004).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of TNFAIP3:RIPK1 [cytosol]
Physical Entity
Activity
Orthologous Events