OTUD7B,TNFAIP3 deubiquitinate TRAF6

Stable Identifier
R-HSA-5690870
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

OTUD7D (Cezanne) negatively regulates the non-canonical NFkappaB pathway by removing Lys-48-linked polyubiquitin chains from TRAF6, preventing TRAF6 proteolysis, which causes over-activation of non-canonical NFkappaB and negative regulation of B-cell responses (Evans et al. 2001).

TNFAIP3 has the opposite effect, it can remove K63-linked ubiquitin from TRAF6, which terminates signalling by Toll-like receptors (Boone et al. 2004). TNFAIP3 is essential for the termination of NFkappaB activation in response to multiple stimuli such as IL-1beta, TNF, IL-6, CD40 and lipopolysaccharide (LPS) (Vereecke et al. 2009).

Literature References
PubMed ID Title Journal Year
11463333 Isolation and characterization of two novel A20-like proteins

Evans, PC, Taylor, ER, Coadwell, J, Heyninck, K, Beyaert, R, Kilshaw, PJ

Biochem. J. 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Lys48-specific deubiquitinase activity of OTUD7B,TNFAIP3,ZRANB1:K48polyUb-TRAF6 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed