Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER

Stable Identifier
R-HSA-5690991
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ERCC1:ERCC4 (ERCC1:XPF) DNA endonuclease complex binds 5' to the DNA damage at global genome nucleotide excision repair (GG-NER) sites to form the incision complex. Binding of ERCC5 (XPG) to the NER site precedes the recruitment of ERCC1:ERCC4 (Riedl et al. 2003). ERCC1 directly interacts with XPA, and this interaction is necessary for the loading of ERCC1:ERCC4 to the open bubble structure in damaged dsDNA and the progression of GG-NER (Tsodikov et al. 2007, Orelli et al. 2010).

Literature References
PubMed ID Title Journal Year
14517266 The comings and goings of nucleotide excision repair factors on damaged DNA

Riedl, T, Hanaoka, F, Egly, JM

EMBO J. 2003
19940136 The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways

Orelli, B, McClendon, TB, Tsodikov, OV, Ellenberger, T, Niedernhofer, LJ, Schärer, OD

J. Biol. Chem. 2010
17948053 Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA

Tsodikov, OV, Ivanov, D, Orelli, B, Staresincic, L, Shoshani, I, Oberman, R, Schärer, OD, Wagner, G, Ellenberger, T

EMBO J. 2007
Participants
Participant Of
Event Information
Orthologous Events
Authored
Reviewed
Created