Ligation of newly synthesized repair patch to incised DNA in GG-NER

Stable Identifier
R-HSA-5690997
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The nucleotide excision repair (NER) is completed when the newly synthesized fragment is ligated to the incised DNA strand, thus closing the single stranded nick (SSB). Two DNA ligases, LIG1 and LIG3 (as part of the LIG3:XRCC1 complex) can perform the ligation in global genome NER (GG-NER), as well as in transcription-coupled NER (TC-NER). The choice of NER DNA ligase depends on the DNA polymerase involved in the repair synthesis and on the stage of the cell cycle (Moser et al. 2007).

Literature References
PubMed ID Title Journal Year
17643379 Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner

Moser, J, Kool, H, Giakzidis, I, Caldecott, K, Mullenders, LH, Fousteri, M

Mol. Cell 2007
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Catalyst Activity
Catalyst Activity
Title
DNA ligase activity of LIG1,LIG3:XRCC1 [nucleoplasm]
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Activity
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Reviewed
Created