Ligation of newly synthesized repair patch to incised DNA in GG-NER

Stable Identifier
R-HSA-5690997
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The nucleotide excision repair (NER) is completed when the newly synthesized fragment is ligated to the incised DNA strand, thus closing the single stranded nick (SSB). Two DNA ligases, LIG1 and LIG3, can perform the ligation in global genome NER (GG-NER), as well as in transcription-coupled NER (TC-NER) (Arakawa et al. 2012, Paul-Konietzko et al. 2015).
Literature References
PubMed ID Title Journal Year
26131740 DNA Ligases I and III Support Nucleotide Excision Repair in DT40 Cells with Similar Efficiency

Arakawa, H, Paul-Konietzko, K, Iliakis, G, Thomale, J

Photochem Photobiol 2015
22127868 Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells

Arakawa, H, Bednar, T, Wang, M, Mladenov, E, Bencsik-Theilen, AA, Iliakis, G, Paul, K

Nucleic Acids Res 2012
Participants
Participates
Catalyst Activity

DNA ligase activity of LIG1,LIG3:XRCC1 [nucleoplasm]

Authored
Reviewed
Created
Cite Us!